Results 61 to 70 of about 58,538 (245)

Association between dietary retinol and prognosis of patients with esophageal squamous cell carcinoma

Shanghai yufang yixue, 2022
ObjectiveTo explore the association between dietary retinol intake and prognosis of patients with esophageal squamous cell carcinoma.MethodsThe study enrolled 388 cases with primary esophageal squamous cell carcinoma that was pathologically diagnosed in ...
ZENG Qiaoyan, ZHANG Juwei, WANG Jianwen, ZHOU Jinsong, QIU Minglian, LIU Shuang, HU Zhijian   +6 more
doaj   +1 more source

Loss of Retinol-Binding Properties for Plasma Retinol-Binding Protein in Normal Human Epidermis [PDF]

, 1987
Terminal differentiation of the keratinocytes (cornification) has been linked to a restricted supply of retinol. Retinol is distributed to target cells by the retinol-binding protein (RBP), which circulates in the plasma in complex with transthyretin ...
Georges Siegenthaler, Jean-Hilaire Saurat, Saurat, Jean-Hilaire, Siegenthaler, Georges   +3 more
core   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Mechanism of pH-induced Release of Retinol from Retinol-Binding Protein [PDF]

, 1993
A hypothesis is proposed explaining the mechanism of pH-induced release of retinol from retinol-binding protein (RBP). A number of conservative positively charged side chains located on the retinol-binding face of the RBP molecule are involved in salt ...
A.L. Denesyuk, G. Zanotti, Ptitsyn, O.B., V.E. Bychkova, ZANOTTI, GIUSEPPE, DENESYUK A. I., BYCHKOVA V. E., O.B. Ptitsyn, Zanotti, G., PTYTSIN O. B., Denesyuk, A.L., Bychkova, V.E.   +11 more
core   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Age‐Dependent Prognostic Significance of Preoperative Transthyretin After Curative Resection for Stage I–III Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Preoperative malnutrition and systemic inflammation are established determinants of adverse outcomes in colorectal cancer (CRC). Transthyretin (TTR), a rapid‐turnover hepatic protein, reflects both nutritional and inflammatory status; however, its clinical utility may be influenced by age‐ and sex‐related variability.
Ayane Kawata, Yuji Miyamoto, Hiro Nakamura, Takahiko Akiyama, Kota Arima, Katsuhiro Ogawa, Yukiharu Hiyoshi, Masaaki Iwatsuki   +7 more
wiley   +1 more source

Genetic influences on circulating retinol and its relationship to human health

Nature Communications
Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Here, we perform the largest genome-wide association study (GWAS) of retinol to date in up to 22,274 participants. We identify eight
William R. Reay, Dylan J. Kiltschewskij, Maria A. Di Biase, Zachary F. Gerring, Kousik Kundu, Praveen Surendran, Laura A. Greco, Erin D. Clarke, Clare E. Collins, Alison M. Mondul, Demetrius Albanes, Murray J. Cairns   +11 more
doaj   +1 more source

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation

American Journal of Hematology, EarlyView.
ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part ...
Marilou Tetard, Tianjian Lin, Nana A. Peterson, Rebekah C. Gullberg, Yann Le Guen, Jasmine Moshiri, John G. Doench, Elizabeth S. Egan   +7 more
wiley   +1 more source

Utilidad de un método que determina simultáneamente retinol y α-tocoferol en leche materna por cromatografía líquida de alta resolución

Perinatología y Reproducción Humana, 2016
Objetivo: Reportar la utilidad de un método simplificado con extracción directa de la leche materna y detección por cromatografía líquida de alta resolución en fase inversa, para la cuantificación de retinol y α-tocoferol.
H. Martínez-Rojano, R. Sámano, M. Tolentino, R.M. Morales Hernández, C. Ramírez, M.L. Pizano Zárate   +5 more
doaj   +1 more source

Plasma kinetics of vitamin A in humans after a single oral dose of [8,9,19-13C]retinyl palmitate

Journal of Lipid Research, 1996
The kinetics of vitamin A and its major metabolites were investigated in humans. Eleven healthy male subjects ingested 105 mumol (100,000 IU) of [8,9,19-13C]retinyl palmitate in an oily solution.
D V Reinersdorff, E Bush, D J Liberato
doaj   +1 more source