Results 71 to 80 of about 57,945 (224)

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Mechanism of pH-induced Release of Retinol from Retinol-Binding Protein [PDF]

, 1993
A hypothesis is proposed explaining the mechanism of pH-induced release of retinol from retinol-binding protein (RBP). A number of conservative positively charged side chains located on the retinol-binding face of the RBP molecule are involved in salt ...
A.L. Denesyuk, G. Zanotti, Ptitsyn, O.B., V.E. Bychkova, ZANOTTI, GIUSEPPE, DENESYUK A. I., BYCHKOVA V. E., O.B. Ptitsyn, Zanotti, G., PTYTSIN O. B., Denesyuk, A.L., Bychkova, V.E.   +11 more
core   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Association between dietary retinol and prognosis of patients with esophageal squamous cell carcinoma

Shanghai yufang yixue, 2022
ObjectiveTo explore the association between dietary retinol intake and prognosis of patients with esophageal squamous cell carcinoma.MethodsThe study enrolled 388 cases with primary esophageal squamous cell carcinoma that was pathologically diagnosed in ...
ZENG Qiaoyan, ZHANG Juwei, WANG Jianwen, ZHOU Jinsong, QIU Minglian, LIU Shuang, HU Zhijian   +6 more
doaj   +1 more source

Age‐Dependent Prognostic Significance of Preoperative Transthyretin After Curative Resection for Stage I–III Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Preoperative malnutrition and systemic inflammation are established determinants of adverse outcomes in colorectal cancer (CRC). Transthyretin (TTR), a rapid‐turnover hepatic protein, reflects both nutritional and inflammatory status; however, its clinical utility may be influenced by age‐ and sex‐related variability.
Ayane Kawata, Yuji Miyamoto, Hiro Nakamura, Takahiko Akiyama, Kota Arima, Katsuhiro Ogawa, Yukiharu Hiyoshi, Masaaki Iwatsuki   +7 more
wiley   +1 more source

Genetic influences on circulating retinol and its relationship to human health

Nature Communications
Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Here, we perform the largest genome-wide association study (GWAS) of retinol to date in up to 22,274 participants. We identify eight
William R. Reay, Dylan J. Kiltschewskij, Maria A. Di Biase, Zachary F. Gerring, Kousik Kundu, Praveen Surendran, Laura A. Greco, Erin D. Clarke, Clare E. Collins, Alison M. Mondul, Demetrius Albanes, Murray J. Cairns   +11 more
doaj   +1 more source

Utilidad de un método que determina simultáneamente retinol y α-tocoferol en leche materna por cromatografía líquida de alta resolución

Perinatología y Reproducción Humana, 2016
Objetivo: Reportar la utilidad de un método simplificado con extracción directa de la leche materna y detección por cromatografía líquida de alta resolución en fase inversa, para la cuantificación de retinol y α-tocoferol.
H. Martínez-Rojano, R. Sámano, M. Tolentino, R.M. Morales Hernández, C. Ramírez, M.L. Pizano Zárate   +5 more
doaj   +1 more source

Plasma kinetics of vitamin A in humans after a single oral dose of [8,9,19-13C]retinyl palmitate

Journal of Lipid Research, 1996
The kinetics of vitamin A and its major metabolites were investigated in humans. Eleven healthy male subjects ingested 105 mumol (100,000 IU) of [8,9,19-13C]retinyl palmitate in an oily solution.
D V Reinersdorff, E Bush, D J Liberato
doaj   +1 more source

Comparison of the Effects of Supplemental Red Palm Oil and Sunflower oil on Maternal Vitamin A Status. [PDF]

, 2001
Conflicting results have been reported on the ability of dietary carotenoids to improve vitamin A status in lactating women. Red palm oil is one of the richest dietary sources of beta-carotene.
Mugyabuso, J K, Ndossi, G D, Lorri, W, Henry, C J, Ballart, A, Tomkins, A, Mulokozi, G, Lietz, G   +7 more
core  

Retinol Uptake by Isolated Retinol Pigment Epithelium Plasma Membranes

, 1981
The uptake of retinol has been investigated by incubating suspensions of isolated bovine retinal pigment epithelium plasma membranes in the presence of [3H]retinol-retinol-binding protein complex. After SDS gel electrophoresis of the labelled membranes, [
OTTONELLO, Simone, Maraini G., MARAINI, Giovanni, Ottonello S.   +3 more
core   +1 more source