Results 51 to 60 of about 16,382,176 (245)

Serum retinol-binding protein 4 levels in polycystic ovary syndrome

Endocrine Connections, 2019
Objective: Serum levels of retinol-binding protein 4 (RBP4), an adipokine thought to affect systemic insulin sensitivity, were compared between women with polycystic ovary syndrome (PCOS) and non-PCOS controls to evaluate the association of RBP4 with ...
Shilpa Lingaiah, Laure Morin-Papunen, Terhi Piltonen, Inger Sundström-Poromaa, Elisabet Stener-Victorin, Juha S Tapanainen   +5 more
doaj   +1 more source

Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression

Journal of Lipid Research, 2022
Hepatocytes secrete retinol-binding protein 4 (RBP4) into circulation, thereby mobilizing vitamin A from the liver to provide retinol for extrahepatic tissues. Obesity and insulin resistance are associated with elevated RBP4 levels in the blood. However,
Julia S. Steinhoff, Carina Wagner, Ulrike Taschler, Sascha Wulff, Marie F. Kiefer, Konstantin M. Petricek, Sylvia J. Wowro, Moritz Oster, Roberto E. Flores, Na Yang, Chen Li, Yueming Meng, Manuela Sommerfeld, Stefan Weger, Andrea Henze, Jens Raila, Achim Lass, Michael Schupp   +17 more
doaj   +1 more source

Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo [PDF]

Journal of Biological Chemistry, 2009
Retinol-binding protein 4 (RBP4) transports retinol from the liver to extrahepatic tissues, and RBP4 lowering is reported to improve insulin sensitivity in mice. We have identified A1120, a high affinity (K(i) = 8.3 nm) non-retinoid ligand for RBP4, which disrupts the interaction between RBP4 and its binding partner transthyretin.
Alykhan, Motani, Zhulun, Wang, Marion, Conn, Karen, Siegler, Ying, Zhang, Qingxiang, Liu, Sheree, Johnstone, Haoda, Xu, Steve, Thibault, Yingcai, Wang, Pingchen, Fan, Richard, Connors, Hoa, Le, Guifen, Xu, Nigel, Walker, Bei, Shan, Peter, Coward   +16 more
openaire   +2 more sources

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Adipokines mediate cardiometabolic risk associated with obesity but their role in the pathogenesis of obesity‐associated heart failure remains uncertain.
Beatrice von Jeinsen, Meghan I. Short, Vanessa Xanthakis, Herman Carneiro, Susan Cheng, Gary F. Mitchell, Ramachandran S. Vasan   +6 more
doaj   +1 more source

Critical role of HMGA proteins in regulation of ATM expression and in cellular response to DNA damage [PDF]

, 2009
MGA proteins are a family of chromatin remodelers involved in many cellular processes including regulation of gene expression, apoptosis and cell proliferation.
Palmieri, Dario
core   +1 more source

Quantitative mass spectrometry evaluation of human retinol binding protein 4 and related variants. [PDF]

PLoS ONE, 2011
Retinol Binding Protein 4 (RBP4) is an exciting new biomarker for the determination of insulin resistance and type 2 diabetes. It is known that circulating RBP4 resides in multiple variants which may provide enhanced clinical utility, but conventional ...
Urban A Kiernan, David A Phillips, Olgica Trenchevska, Dobrin Nedelkov   +3 more
doaj   +1 more source

Sexual dimorphism in developmental and diet‐dependent circulating retinol binding protein 4

Obesity Science & Practice, 2018
Summary Objective Retinol binding protein 4 (RBP4) transports vitamin A (Retinol) in the blood and contributes mechanistically to the linkage between obesity, insulin resistance and associated comorbidities including type 2 diabetes mellitus, coronary ...
S. Bakshi, H. M. Schmidt, A. E. Baskin, C. M. Croniger, C. L. Thompson, T. Bonfield, D. Fletcher, N. A. Berger   +7 more
doaj   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

Decreased Retinol Binding Protein 4 Concentrations are Associated With Cholesterol Gallstone Disease

Journal of the Formosan Medical Association, 2010
Circulating retinol binding protein 4 (RBP4) is associated with a variety of obesity-related diseases. This study investigated whether there were aberrant concentrations of RBP4 in cholesterol gallstone disease.
Shen-Nien Wang, Yao-Tsung Yeh, Sen-Teh Wang, Yi-Ling Chen, Shih-Chang Chuang, Chen-Guo Ker, King-Teh Lee   +6 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source