Results 71 to 80 of about 50,629 (277)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients. [PDF]

PLoS ONE, 2013
Retinol binding protein 4 (RBP4) is an adipokine that may contribute to the development of insulin resistance. However, how this adipokine is affected and its possible involvement in lipid metabolism in obese patients with varying degrees of insulin ...
Milagros Rocha, Celia Bañuls, Lorena Bellod, Susana Rovira-Llopis, Carlos Morillas, Eva Solá, Víctor M Víctor, Antonio Hernández-Mijares   +7 more
doaj   +1 more source

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, EarlyView.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundAdipokines are elaborated by adipose tissue and are associated with glycemic, lipid, and vascular traits. We hypothesized that in a cross‐sectional analysis circulating adipokines are altered among subsets of obesity stratified by presence ...
Justin P. Zachariah, Rene Quiroz, Kerrie P. Nelson, Zhaoyang Teng, John F. Keaney, Lisa M. Sullivan, Ramachandran S. Vasan   +6 more
doaj   +1 more source

Circulating Retinol-Binding Protein 4 as a Possible Biomarker of Treatment Response for Ankylosing Spondylitis: An Array-Based Comparative Study

Frontiers in Pharmacology, 2020
ObjectiveTo explore proteins associated with ankylosing spondylitis (AS) and to investigate potential proteins that may predict treatment response of adalimumab (ADA) in AS patients.MethodsIn the discovery cohort, 39 AS patients and 20 healthy controls ...
Jialing Wu, Xinyu Wu, Zena Chen, Qing Lv, Mingcan Yang, Xuqi Zheng, Qiuxia Li, Yanli Zhang, Qiujing Wei, Shuangyan Cao, Xiaomin Li, Jun Qi, Minjing Zhao, Zetao Liao, Zhiming Lin, Jieruo Gu   +15 more
doaj   +1 more source

Studies relating to protein expression in the uterus of the cow [PDF]

, 2007
End of project reportEmbryo loss is a major cause of reproductive wastage in the cow. The majority of embryo loss occurs in the first 16 days after fertilisation when the embryo is critically dependent on the maternal uterine environment for survival ...
Costello, L.M., Diskin, Michael G., Hynes, A.C., Morris, Dermot G., Sreenan, J.M.   +4 more
core  

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Adipose Tissue Depots and Their Cross‐Sectional Associations With Circulating Biomarkers of Metabolic Regulation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundVisceral adipose tissue (VAT) and fatty liver differ in their associations with cardiovascular risk compared with subcutaneous adipose tissue (SAT).
Jane J. Lee, Kathryn A. Britton, Alison Pedley, Joseph M. Massaro, Elizabeth K. Speliotes, Joanne M. Murabito, Udo Hoffmann, Cheryl Ingram, John F. Keaney, Ramachandran S. Vasan, Caroline S. Fox   +10 more
doaj   +1 more source

The High Plasma Retinol Binding Protein 4 Level as a Risk Factor Consequently of Type 2 Diabetes Mellitus of Abdominal Obesity [PDF]

, 2011
Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM).
Astawa, N. M. (Nyoman), Budhitresna, A. (AAG), Santoso, A. (Anwar), Suastika, K. (Ketut)   +3 more
core  

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
core   +4 more sources