Metabolism and secretion of retinol transport complex in acute renal failure
Journal of Lipid Research, 1991 Tissue uptake and distribution of retinol from circulatory vitamin A transport complex was studied in order to determine the origin of the increased serum retinol in rats with short-term acute renal failure.
TH Gerlach, MH Zile
doaj +3 more sources
Beyond a gatekeeper: the non-classical signaling role of STRA6 in driving endothelial senescence and atherosclerosis [PDF]
Frontiers in ImmunologyEndothelial cell (EC) senescence is a fundamental driver of atherosclerosis. This review posits that the primary pathogenic role of Stimulated by Retinoic Acid 6 (STRA6) in the endothelium is not its canonical vitamin A transport but its non-classical ...
Yong Yuan +7 more
doaj +2 more sources
The Potential Role of Retinol-Binding Protein 4 in Heart Failure: A Review [PDF]
Reviews in Cardiovascular MedicineHeart failure (HF) is a heterogeneous clinical syndrome, the prevalence of which is increasing among younger adults, promoting global concern due to its significant morbidity and mortality.
Jiayi Liu, Yaping Wang
doaj +2 more sources
BiomedicinesBackground: The protein that binds to retinol 4 (RBP4), is a lipocalin-family protein, secreted primarily by the adipose tissue and the liver, and has also been reported to be produced by other tissues, including the kidney.
María Paz Nieto-Bona +2 more
doaj +2 more sources
Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport [PDF]
Clinical and Translational Medicine, 2023 Aleksha Panwar +11 more
doaj +2 more sources
Histopathological Characteristics and Multi-Omics Analysis of Ocular Pigmentation Defects in Albino Percocypris pingi [PDF]
CellsPercocypris pingi was listed in the China Vertebrate Red List in 2015, and albino P. pingi exhibits remarkable ocular phenotypes due to melanin synthesis defects, including the deficiency of melanin granules in the iris and retinal pigment epithelium ...
Senyue Liu +12 more
doaj +2 more sources
Biological Functions of RBP4 and Its Relevance for Human Diseases
Frontiers in Physiology, 2021 Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation.
Julia S. Steinhoff +3 more
doaj +1 more source
The transport of retinol in human plasma [PDF]
FEBS Letters, 1969 Evidence in support of the view that tryptophanrich prealbumin [l] may serve as the specific transport protein for retinol in human plasma has previously been reported by Alvsaker, Haugli and Laland [2]. Since thyroxine is transported partly by this protein [3] , thyroxine and retinol would then share the same transport protein. In order to investigate
Johannessen, S. +2 more
openaire +2 more sources
An in vitro model for vitamin A transport across the human blood–brain barrier
eLife, 2023 Vitamin A, supplied by the diet, is critical for brain health, but little is known about its delivery across the blood–brain barrier (BBB). Brain microvascular endothelial-like cells (BMECs) differentiated from human-derived induced pluripotent stem ...
Chandler B Est, Regina M Murphy
doaj +1 more source
Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction [PDF]
, 2021 Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of pro-amyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology.
Arun, Raja +7 more
core +1 more source