Results 1 to 10 of about 7,318 (257)

Retinol and retinyl esters: biochemistry and physiology [PDF]

Journal of Lipid Research, 2013
By definition, a vitamin is a substance that must be obtained regularly from the diet. Vitamin A must be acquired from the diet, but unlike most vitamins, it can also be stored within the body in relatively high levels.
Sheila M. O'Byrne, William S. Blaner
doaj   +6 more sources

The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver[S] [PDF]

Journal of Lipid Research, 2011
Retinyl esters are the major chemical forms of vitamin A stored in the liver, and can be delivered to peripheral tissues for conversion into biologically active forms.
Wenqiang Pang, Ying Zhang, Shiming Wang, Aiqun Jia, Wei Dong, Chun Cai, Zichun Hua, Jianfa Zhang   +7 more
doaj   +4 more sources

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover [PDF]

Journal of Biological Chemistry, 2016
Lysosomal acid lipase (LAL) is essential for the clearance of endocytosed cholesteryl ester and triglyceride-rich chylomicron remnants. Humans and mice with defective or absent LAL activity accumulate large amounts of cholesteryl esters and triglycerides
Lukas Grumet, Thomas O. Eichmann, Ulrike Taschler, Kathrin A. Zierler, Christina Leopold, Tarek Moustafa, Branislav Radović, Matthias Romauch, Cong Yan, Hong Du, Guenter Haemmerle, Rudolf Zechner, Peter Fickert, Dagmar Kratky, Robert Zimmermann, Achim Lass   +15 more
core   +8 more sources

Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation. [PDF]

PLoS ONE, 2012
Activation of hepatic stellate cells has been recognized as one of the first steps in liver injury and repair. During activation, hepatic stellate cells transform into myofibroblasts with concomitant loss of their lipid droplets (LDs) and production of ...
Nicole Testerink, Mokrish Ajat, Martin Houweling, Jos F Brouwers, Vishnu V Pully, Henk-Jan van Manen, Cees Otto, J Bernd Helms, Arie B Vaandrager   +8 more
doaj   +4 more sources

Do serum vitamins, carotenoids, and retinyl esters influence mortality in osteoarthritis? Insights from a nationally representative study [PDF]

Frontiers in Nutrition
BackgroundThe relationship between serum vitamins, carotenoids, and retinyl esters and mortality risk among individuals with osteoarthritis (OA) remains unclear.
Yifan Lu, Yifan Lu, Junjie Duan, Rong You, Simin Tang, Xinyu Qi, Boyu Wu, Gonghui Jian, Tao Wang, Jianhui Duan, Zhuo Yang   +10 more
doaj   +4 more sources

Retinyl esters form lipid droplets independently of triacylglycerol and seipin. [PDF]

J Cell Biol, 2021
Lipid droplets store neutral lipids, primarily triacylglycerol and steryl esters. Seipin plays a role in lipid droplet biogenesis and is thought to determine the site of lipid droplet biogenesis and the size of newly formed lipid droplets. Here we show a seipin-independent pathway of lipid droplet biogenesis.
Molenaar MR, Yadav KK, Toulmay A, Wassenaar TA, Mari MC, Caillon L, Chorlay A, Lukmantara IE, Haaker MW, Wubbolts RW, Houweling M, Vaandrager AB, Prieur X, Reggiori F, Choudhary V, Yang H, Schneiter R, Thiam AR, Prinz WA, Helms JB.   +19 more
europepmc   +8 more sources

Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase. [PDF]

PLoS ONE, 2011
Retinoids are mostly stored as retinyl esters in hepatic stellate cells (HSCs) through esterification of retinol and fatty acid, catalyzed by lecithin-retinol acyltransferase (LRAT). This study is designated to address how retinyl esters are mobilized in
Yujiro Kida, Zanxian Xia, Sujun Zheng, Nicholas M Mordwinkin, Stan G Louie, Song Guo Zheng, Min Feng, Hongbo Shi, Zhongping Duan, Yuan-Ping Han   +9 more
doaj   +3 more sources

A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters [PDF]

Journal of Lipid Research, 2005
Acyl-CoA-dependent O-acyltransferases catalyze reactions in which fatty acyl-CoAs are joined to acyl acceptors containing free hydroxyl groups to produce neutral lipids.
Chi-Liang Eric Yen, Charles H. Brown, IV, Mara Monetti, Robert V. Farese, Jr.   +3 more
doaj   +2 more sources

Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium. [PDF]

PLoS ONE, 2015
Retinyl esters represent an insoluble storage form of vitamin A and are substrates for the retinoid isomerase (Rpe65) in cells of the retinal pigment epithelium (RPE).
Joanna J Kaylor, Roxana A Radu, Nicholas Bischoff, Jacob Makshanoff, Jane Hu, Marcia Lloyd, Shannan Eddington, Tran Bianconi, Dean Bok, Gabriel H Travis   +9 more
doaj   +2 more sources

Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters.

Journal of Lipid Research, 1993
After the ingestion of a fat-rich meal, there is a postprandial increase in the plasma concentration of both apolipoprotein B-48- and apoB-100-containing triglyceride-rich lipoproteins (apoB-48 and apoB-100 TRL). In order to determine the contribution of
J S Cohn, E J Johnson, J S Millar, S D Cohn, R W Milne, Y L Marcel, R M Russell, E J Schaefer   +7 more
doaj   +2 more sources