Results 11 to 20 of about 3,830 (170)
Journal of Lipid Research, 1995 Previous studies have indicated the presence of both neutral and acid, bile salt-independent retinyl ester hydrolases associated with plasma membrane and endosome fractions of rat liver homogenates. In the present studies, chylomicrons containing tritium-
E H Harrison, M Z Gad, A C Ross
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Hepatic Retinyl Ester Hydrolases and the Mobilization of Retinyl Ester Stores [PDF]
Nutrients, 2016 For mammals, vitamin A (retinol and metabolites) is an essential micronutrient that is required for the maintenance of life. Mammals cannot synthesize vitamin A but have to obtain it from their diet. Resorbed dietary vitamin A is stored in large quantities in the form of retinyl esters (REs) in cytosolic lipid droplets of cells to ensure a constant ...
Lukas Grumet +2 more
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Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase. [PDF]
PLoS ONE, 2011 Retinoids are mostly stored as retinyl esters in hepatic stellate cells (HSCs) through esterification of retinol and fatty acid, catalyzed by lecithin-retinol acyltransferase (LRAT). This study is designated to address how retinyl esters are mobilized in
Yujiro Kida +9 more
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Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation. [PDF]
PLoS ONE, 2012 Activation of hepatic stellate cells has been recognized as one of the first steps in liver injury and repair. During activation, hepatic stellate cells transform into myofibroblasts with concomitant loss of their lipid droplets (LDs) and production of ...
Nicole Testerink +8 more
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Substrate specificity of retinyl ester hydrolase activity in retinal pigment epithelium
Journal of Lipid Research, 1998 In the eye, hydrolysis of stored retinyl esters is catalyzed by retinyl ester hydrolase (REH) activities in retinal pigment epithelium (RPE) membranes.
Jennifer R. Mata +2 more
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Vitamin A metabolism: analysis of steady-state neutral metabolites in rat tissues.
Journal of Lipid Research, 1984 High-performance liquid chromatography systems were developed to rapidly separate retinol from its esters, analyze the total spectrum of neutral vitamin A compounds, and purify retinyl esters to homogeneity.
J B Williams, B C Pramanik, J L Napoli
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Journal of Lipid Research, 1991 We recently reported the presence of a neutral, bile salt-independent retinyl ester hydrolase (REH) activity in rat liver microsomes and showed that it was distinct from the previously studied bile salt-dependent REH and from nonspecific ...
MZ Gad, EH Harrison
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Journal of Lipid Research, 1992 An efficient protocol is described for the study of the kinetics of retinyl esters in whole plasma and several lipoprotein fractions following the consumption of an oral fat load containing vitamin A (retinol).
G Ruotolo, H Zhang, V Bentsianov, NA Le
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Biological Functions of RBP4 and Its Relevance for Human Diseases
Frontiers in Physiology, 2021 Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation.
Julia S. Steinhoff +3 more
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PLoS ONE, 2022 Chronic alcohol consumption leads to a spectrum of liver disease that is associated with significant global mortality and morbidity. Alcohol is known to deplete hepatic vitamin A content, which has been linked to the pathogenesis of alcoholic liver ...
Afroza Ferdouse +5 more
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