Retinoid Metabolism and Diabetes Mellitus [PDF]
Diabetes & Metabolism Journal, 2012 Retinoid acid is a metabolite of vitamin A and functions as an important factor in cell survival, differentiation and death. Most previous studies on retinoid metabolism have focused on its association with cancer, hematologic and dermatologic disorders.
Eun-Jung Rhee, Jorge Plutzky
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Retinoid metabolism: new insights. [PDF]
J Mol Endocrinol, 2022 Vitamin A (retinol) is a critical micronutrient required for the control of stem cell functions, cell differentiation, and cell metabolism in many different cell types, both during embryogenesis and in the adult organism. However, we must obtain vitamin A from food sources.
Gudas LJ.
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Retinoid metabolism and functions mediated by retinoid binding-proteins. [PDF]
Methods Enzymol, 2020 Cellular retinoid-binding proteins (BP) chaperone retinol through esterification, conversion of retinol into retinal, reduction of retinal, conversion of retinal into all-trans-retinoic acid (ATRA), and ATRA to catabolism. They also deliver ATRA to nuclear receptors and mediate non-genomic ATRA actions. These retinoid-specific binding-proteins include:
Napoli JL, Yoo HS.
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Effect of Hyperoxia on Retinoid Metabolism and Retinoid Receptor Expression in the Lungs of Newborn Mice. [PDF]
PLoS ONE, 2015 Preterm newborns that receive oxygen therapy often develop bronchopulmonary dysplasia (BPD), which is abnormal lung development characterized by impaired alveologenesis.
Hsing-Jin Chen, Bor-Luen Chiang
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Dysregulated glycosaminoglycan biosynthesis and retinoid metabolism in chronic rhinosinusitis with nasal polyps: insights from a comprehensive transcriptomic analysis [PDF]
Frontiers in ImmunologyBackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory condition affecting 5–12% of the population. Despite its prevalence, the underlying pathophysiological mechanisms remain incompletely understood, representing an unmet ...
Nelli Nepp +10 more
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Bringing retinoid metabolism into the 21st century1 [PDF]
Journal of Lipid Research, 2009 The requirement of vitamin A (retinoids) for normal growth has been recognized for almost a century (1, 2). It plays an important role in a number of physiological processes including vision, cell differentiation, reproduction, and immunity. Vitamin A is a fat-soluble organic compound that cannot be synthesized endogenously by humans and thus, it is an
Theo J.C. van Berkel
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Journal of Lipid Research, 2000 Hepatocytes and hepatic stellate cells play important roles in retinoid storage and metabolism. Hepatocytes process postprandial retinyl esters and are responsible for secretion of retinol bound to retinol-binding protein (RBP) to maintain plasma retinol
Silke Vogel +6 more
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Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression [PDF]
The Journal of Clinical InvestigationLysine-specific demethylase 1 (LSD1; KDM1A) orchestrates context-dependent chromatin programs, yet its role in epithelial immunity remains largely unknown.
Nina Kuprasertkul +20 more
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Fatty acid transport protein 1 regulates retinoid metabolism and photoreceptor development in mouse retina. [PDF]
PLoS ONE, 2017 In retinal pigment epithelium (RPE), RPE65 catalyzes the isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol in the visual cycle and controls the rhodopsin regeneration rate.
Aurélie Cubizolle +4 more
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Putrescine treatment reverses α-tocopherol-induced desynchronization of polyamine and retinoid metabolism during rat liver regeneration [PDF]
Journal of Translational Medicine, 2016 Background The pre-treatment with α-tocopherol inhibits progression of rat liver proliferation induced by partial hepatectomy (PH), by decreasing and/or desynchronizing cyclin D1 expression and activation into the nucleus, activation and nuclear ...
Lourdes Sánchez-Sevilla +2 more
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