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Retinyl Ester Analysis by Orbitrap Mass Spectrometry
, 2023 Retinoids are light-sensitive molecules that are normally detected by UV absorption techniques. Here we describe the identification and quantification of retinyl ester species by high-resolution mass spectrometry. Retinyl esters are extracted by the method of Bligh and Dyer and subsequently separated by HPLC in runs of 40 min.
Jansen, Jeroen W A +3 more
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Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6. [PDF]
, 2015 Vitamin A has biological functions as diverse as sensing light for vision, regulating stem cell differentiation, maintaining epithelial integrity, promoting immune competency, regulating learning and memory, and acting as a key developmental morphogen ...
Kassai, Miki +4 more
core +2 more sources
Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]
, 2014 Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO +7 more
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Characterization of liver stellate cell retinyl ester storage [PDF]
Biochemical Journal, 1994 The stellate cells of the liver are the main storage site of retinyl esters in the body. During cultivation in vitro of stellate cells isolated from rat and rabbit livers were observed that the cells rapidly loose their retinyl ester content. Freshly isolated stellate cells contain about 144 nmol of total retinol/mg of protein, while cells cultivated ...
G, Trøen +3 more
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Substrate specificity of retinyl ester hydrolase activity in retinal pigment epithelium
Journal of Lipid Research, 1998 In the eye, hydrolysis of stored retinyl esters is catalyzed by retinyl ester hydrolase (REH) activities in retinal pigment epithelium (RPE) membranes.
Jennifer R. Mata +2 more
doaj +1 more source
Existing and emerging technologies for measuring stable isotope labelled retinol in biological samples: isotope dilution analysis of body retinol stores [PDF]
, 2014 This paper discusses some of the recent improvements in instrumentation used for stable isotope tracer measurements in the context of measuring retinol stores, in vivo.
Preston, Tom
core +1 more source
Vitamin A metabolism: analysis of steady-state neutral metabolites in rat tissues.
Journal of Lipid Research, 1984 High-performance liquid chromatography systems were developed to rapidly separate retinol from its esters, analyze the total spectrum of neutral vitamin A compounds, and purify retinyl esters to homogeneity.
J B Williams, B C Pramanik, J L Napoli
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Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD) [PDF]
, 2017 Vitamin A is required for important physiological processes, including embryogenesis, vision, cell proliferation and differentiation, immune regulation, and glucose and lipid metabolism.
Blokzijl, Hans +4 more
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Journal of Lipid Research, 1991 We recently reported the presence of a neutral, bile salt-independent retinyl ester hydrolase (REH) activity in rat liver microsomes and showed that it was distinct from the previously studied bile salt-dependent REH and from nonspecific ...
MZ Gad, EH Harrison
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Retinyl ester hydrolases and their roles in vitamin A homeostasis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2011 In mammals, dietary vitamin A intake is essential for the maintenance of adequate retinoid (vitamin A and metabolites) supply of tissues and organs. Retinoids are taken up from animal or plant sources and subsequently stored in form of hydrophobic, biologically inactive retinyl esters (REs). Accessibility of these REs in the intestine, the circulation,
Renate Schreiber +5 more
openalex +3 more sources