Results 51 to 60 of about 3,830 (170)

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, Volume 59, Issue 7, July 2026.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Bakuchiol Ferulate: A Novel Functional Retinol Analog With Enhanced Photostability and Reduced Phototoxicity for Cosmetic Applications

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Retinol (ROL) is essential in dermatology for antiaging; however, its clinical utility is frequently limited by inherent chemical instability and significant cutaneous irritation. Objective This study describes the development of bakuchiol ferulate (BF), a novel molecular hybrid synthesized from bakuchiol and a ferulic acid (FA ...
Jiangming Zhong, Yizhen Yan, Nan Zhao, Xinyu Cao, Yuting Liang, Qi Zhou, Jinjing Bao, Zhiwei Li, Qiaoyuan Liu, Meixin Lu, Qing Liu, Bin Shuai, Rong Hu, Peng Shu   +13 more
wiley   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, Volume 3, Issue 2, June 2026.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2

Journal of Lipid Research, 2017
The esterification of alcohols with fatty acids is a universal mechanism to form inert storage forms of sterols, di- and triacylglycerols, and retinoids. In ocular tissues, formation of retinyl esters is an essential step in the enzymatic regeneration of
Jason M. Arne, Made Airanthi K. Widjaja-Adhi, Taylor Hughes, Kevin W. Huynh, Josie A. Silvaroli, Sylwia Chelstowska, Vera Y. Moiseenkova-Bell, Marcin Golczak   +7 more
doaj   +1 more source

Synergistic Interaction Between HPV‐16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Persistent infection with High‐Risk Human Papillomavirus (HR‐HPV), particularly HPV‐16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR‐HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia ...
Armando Chávez‐Ríos, Celina López‐Ruiz, Ian A. García‐Aguirre, Rodolfo Ocadiz‐Delgado, Francisco Garcia‐Sierra, Rogelio Hernández‐Pando, Solangy Lizcano‐Meneses, Patricio Gariglio   +7 more
wiley   +1 more source

Unusual properties of retinyl palmitate hydrolase activity in rat liver.

Journal of Lipid Research, 1979
These studies report the hydrolysis of retinyl palmitate with liver homogenates and homogenate fractions from retinol-depleted rats. The studies utilized an effective in vitro assay for retinyl palmitate hydrolase (RPH) activity, in which microgram ...
E H Harrison, J E Smith, D S Goodman
doaj   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

A Method to Identify and Isolate Pluripotent Human Stem Cells and Mouse Epiblast Stem Cells Using Lipid Body-Associated Retinyl Ester Fluorescence

Stem Cell Reports, 2014
We describe the use of a characteristic blue fluorescence to identify and isolate pluripotent human embryonic stem cells and human-induced pluripotent stem cells.
Thangaselvam Muthusamy, Odity Mukherjee, Radhika Menon, Megha Prakash Bangalore, Mitradas M. Panicker   +4 more
doaj   +1 more source

Advances in cholesterol and lipoproteins detection for healthcare: A review

VIEW, Volume 7, Issue 3, June 2026.
Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta, Somayeh Fardindoost, Azadeh Abdi, Kaveh Yazdani, Longfei Yin, Syamak Farajikhah, Mina Hoorfar, Fariba Dehghani   +7 more
wiley   +1 more source

Compartmental modeling of whole-body vitamin A kinetics in unsupplemented and vitamin A-retinoic acid-supplemented neonatal rats[S]

Journal of Lipid Research, 2014
Little is known about the contribution of different tissues to whole-body vitamin A (VA) kinetics in neonates. Here, we have used model-based compartmental analysis of tissue tracer kinetic data from unsupplemented (control) and VA-retinoic acid (VARA ...
Libo Tan, Amanda E. Wray, Michael H. Green, A. Catharine Ross   +3 more
doaj   +1 more source