Results 241 to 250 of about 995,941 (287)

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Cancer Science, EarlyView.
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng   +11 more
wiley   +1 more source

The Serotonergic and Cholinergic Signaling Pathways Drive Gastric Precancerous Lesions and Its Potential Mechanism

Cancer Science, EarlyView.
Vagal cholinergic neurons promote gastric 5‐HT secretion, which drives gastric precancerous lesions through 5‐HTR1D and TRPV4, highlighting these as candidate targets for early intervention. ABSTRACT Gastric cancer (GC) is a leading lethal malignancy globally. Gastric precancerous lesion (GPL) represents a critical step in GC, but its neural regulatory
Shengli Gao, Xufei Feng, Nana Zhang, Jia Su, Yuyan Wang, Linghan Kong, Jianing Zhou, Hui Dong, Feifei Guo   +8 more
wiley   +1 more source

Pathological Ossification of Spinal Ligament‐Derived Fibroblasts in an Inflammatory Micro‐Environment via Activation of the ECM/ITGA5/FAK/AKT Pathway in Ankylosing Spondylitis

Cell Proliferation, EarlyView.
Schematic diagram illustrating the activation of the ECM/ITGA5/FAK/AKT axial signalling pathway in the osteogenic transdifferentiation of AS ligaments‐derived fibroblasts and the simulation of ectopic ossification via subcutaneous transplantation in vivo.
Mu Qiao, Kai‐Yang Wang, Chen‐Yu Song, Jing‐Shun Lu, Jiu‐Kun Li, Yong Qiu, Bang‐Ping Qian, Ze‐Zhang Zhu   +7 more
wiley   +1 more source

Continuing automated insulin delivery systems during hospitalisation with type 1 diabetes: A thematic literature review

Diabetic Medicine, EarlyView.
Abstract Aims A thematic review that identifies and summarises available evidence for people with Type 1 diabetes (T1D) continuing automated insulin delivery (AID) systems in the hospital setting, primarily with a focus on assessing the in‐hospital safety and efficacy of AID use.
Hannah Cunningham, Alicia Jenkins, David N. O'Neal, Melissa H. Lee   +3 more
wiley   +1 more source

Amylin Receptor Signalling in the Laterodorsal Tegmental Nucleus Controls Food Intake Through Projections to the Ventral Tegmental Area

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background The role of amylin signalling in energy balance control has been understudied in calcitonin receptor (CTR) expressing nuclei such as the mesopontine laterodorsal tegmental nucleus (LDTg). Our lab has shown that LDTg amylin signalling reduces feeding and body weight, but the neuronal phenotype and downstream targets of LDTgCTR cells ...
Marcos J. Sanchez Navarro, Carlie Zhang, Samantha M. Fortin, Matthew R. Hayes   +3 more
wiley   +1 more source

Was there ever an Animal Dasein? Heidegger's Concept of Life in the 1924 Aristotle Lecture

European Journal of Philosophy, EarlyView.
Abstract This essay examines Heidegger's interpretation of the Aristotelian concept of life in his 1924 lecture Basic Concepts of Aristotelian Philosophy. While scholars have emphasized the text's decisive role in the preparation of Being and Time, their readings have largely centered on the notions of praxis and human existence.
Antonino Firenze
wiley   +1 more source

Arabidopsis transcription factor ANAC102 predominantly expresses a nuclear protein and acts as a negative regulator of methyl viologen-induced oxidative stress responses. [PDF]

J Exp Bot
Luo X, Jiang X, Schmitt V, Kulkarni SR, Tran HC, Kacprzak SM, Van Breusegem F, Van Aken O, Vandepoele K, De Clercq I.   +9 more
europepmc   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source