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Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe   +11 more
wiley   +1 more source
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Mitochondrial Retrograde Signaling

Annual Review of Genetics, 2006
Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus under normal and pathophysiological conditions. The best understood of such pathways is retrograde signaling in the budding yeast Saccharomyces cerevisiae.
Zhengchang, Liu, Ronald A, Butow
openaire   +4 more sources

PLASTID-TO-NUCLEUS RETROGRADE SIGNALING

Annual Review of Plant Biology, 2006
Plant cells store genetic information in the genomes of three organelles: the nucleus, plastid, and mitochondrion. The nucleus controls most aspects of organelle gene expression, development, and function. In return, organelles send signals to the nucleus to control nuclear gene expression, a process called retrograde signaling. This review summarizes
Ajit, Nott   +3 more
openaire   +4 more sources

Retrograde signaling by endocannabinoids

Current Opinion in Neurobiology, 2002
Recent studies suggest that endocannabinoids act as retrograde messengers at many synapses in the central nervous system. Activation of phospholipases, either through calcium-mediated or receptor-mediated signaling, leads to the formation and release of endocannabinoids. These lipophilic signaling molecules diffuse to nearby presynaptic terminals where
Anatol C, Kreitzer, Wade G, Regehr
openaire   +2 more sources

Retrograde signaling in axonal regeneration

Experimental Neurology, 2010
Neuronal regeneration in the peripheral nervous system requires mobilization of intrinsic neurite outgrowth mechanisms. This process depends on retrograde signaling between lesion site and soma to provide accurate and timely information on the nature and extent of axonal damage, and to elicit an appropriate cell body response.
Ida, Rishal, Mike, Fainzilber
openaire   +2 more sources

Metabolites and chloroplast retrograde signaling

Current Opinion in Plant Biology, 2015
Intracellular signaling from chloroplast to nucleus followed by a subsequent response in the chloroplast is called retrograde signaling. It not only coordinates the expression of nuclear and chloroplast genes, which is essential for chloroplast biogenesis, but also maintains chloroplast function at optimal levels in response to fluxes in metabolites ...
Wei, Chi   +3 more
openaire   +2 more sources

Emerging Trends in Retrograde Signaling

Molecular Neurobiology, 2015
Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of retrograde signaling.
Yashasvi, Suvarna   +2 more
openaire   +2 more sources

Long-distance retrograde neurotrophic signaling

Current Opinion in Neurobiology, 2005
The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of ...
Charles L, Howe, William C, Mobley
openaire   +2 more sources

Retrograde Signalling by Endocannabinoids

2005
The cannabinoid neurotransmitter system comprises cannabinoid G protein-coupled membrane receptors (CB1 and CB2), endogenous cannabinoids (endocannabinoids), as well as mechanisms for their synthesis, membrane transport and metabolism. Within the brain the marijuana constituent delta9-tetrahydrocannabinol (THC) produces its pharmacological actions by ...
C W, Vaughan, M J, Christie
openaire   +2 more sources

Studying Retrograde Signaling in Plants

2018
Cellular homeostasis requires precise communication between various types of organelles. In particular, the communication between nucleus and semiautonomous organelles, mitochondria and chloroplasts, has received widespread attention. Communication from nucleus to other organelles is known as anterograde signaling, whereas communication from ...
Martyna, Broda, Olivier, Van Aken
openaire   +2 more sources

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