Results 91 to 100 of about 11,758 (252)
Plant Biotechnology Journal, EarlyView.ABSTRACT High temperature has posed significant challenges to global agriculture, markedly leading to reduced fertility and yield losses in tomato (Solanum lycopersicum). Therefore, thermotolerance‐conferring genes and loci are needed to further improve cultivated tomatoes.
Xiaolin Geng +9 more
wiley +1 more source
Archives of Neurology, 2008 During the tail end of the 20th century, a "golden period" in Alzheimer disease (AD) research, many of the pathogenic molecules of the autosomal dominant form of the disease were isolated. These molecular defects, however, do not exist in "sporadic" late-onset AD, the form of the disease that accounts for more than 95% of all cases.
openaire +2 more sources
VPS35, the Retromer Complex and Parkinson’s Disease [PDF]
Journal of Parkinson’s Disease, 2017 Mutations in the vacuolar protein sorting 35 ortholog ( VPS35) gene encoding a core component of the retromer complex, have recently emerged as a new cause of late-onset, autosomal dominant familial Parkinson’s disease (PD). A single missense mutation, AspD620Asn (D620N), has so far been unambiguously identified to cause PD in multiple individuals and ...
Williams, Erin T. +2 more
openaire +2 more sources
PLoS Biology, 2014 Rhodopsin mistrafficking can cause photoreceptor (PR) degeneration. Upon light exposure, activated rhodopsin 1 (Rh1) in Drosophila PRs is internalized via endocytosis and degraded in lysosomes. Whether internalized Rh1 can be recycled is unknown.
Shiuan Wang +14 more
doaj +1 more source
VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin. [PDF]
, 2015 Mutations in VPS35 (PARK17) cause autosomal dominant, late onset Parkinson's disease (PD). VPS35 forms a core component of the retromer complex that mediates the retrieval of membrane proteins from endosomes back to either the Golgi or plasma membrane ...
Alexander J. Whitworth +3 more
core +3 more sources
Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 128-139, March 2026.ABSTRACT Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mammary carcinoma (FMC) often recurs or metastasizes. Specific tumour biomarkers are necessary for early detection, prognosis and therapy selection.
Pruettha Aruvornlop +7 more
wiley +1 more source
Nature Communications, 2021 NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism to ...
Huibing Wang +13 more
doaj +1 more source
Endosomal Recycling Defects and Neurodevelopmental Disorders
Cells, 2022 The quality and quantity of membrane proteins are precisely and dynamically maintained through an endosomal recycling process. This endosomal recycling is executed by two protein complexes: retromer and recently identified retriever.
Shinji Saitoh
doaj +1 more source
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration [PDF]
, 2014 Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD).
A. Fiser +38 more
core +5 more sources