Results 141 to 150 of about 11,758 (252)

Retromer‐mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21

bioRxiv
Endosomal trafficking ensures the proper distribution of lipids and proteins to various cellular compartments, facilitating intracellular communication, nutrient transport, waste disposal, and the maintenance of cell structure.
M. Romano-Moreno, Elsa N Astorga-Simón, Adriana L Rojas, A. Hierro   +3 more
semanticscholar   +1 more source

Contrasting Retromer with a Newly Described Retriever in Arabidopsis thaliana. [PDF]

Plants (Basel)
The tight regulation of protein composition within the plasma membranes of plant cells is crucial for the proper development of plants and for their ability to respond to a changing environment.
Lewis CD, Tierney ML.
europepmc   +2 more sources

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways. [PDF]

, 2012
The FERM-like domain-containing sorting nexins of the SNX17/SNX27/SNX31 family have been proposed to mediate retrieval of transmembrane proteins from the lysosomal pathway.
Arighi, Bass, Burden, Carlton, Carlton, Caswell, Cullen, Cullen, Dozynkiewicz, Florian Steinberg, Ghai, Gomez, Grant, Harterink, Huss, Johannes, Jović, Kate J. Heesom, Lane, Lauffer, Lee, Li, Lobert, Margadant, Mark D. Bass, Moser, Muhammad, Peter J. Cullen, Roca-Cusachs, Salicioni, Seaman, Seet, Stockinger, Temkin, Tiwari, van Kerkhof, Wassmer, Wassmer, White, Worby, Zech   +40 more
core   +2 more sources

Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate [PDF]

, 2017
The rare human disorder chorea-acanthocytosis (ChAc) is caused by mutations in hVPS13A gene. The hVps13A protein interacts with actin and regulates the level of phosphatidylinositol 4-phosphate (PI4P) in the membranes of neuronal cells.
Ayscough, K.R., Flis, K., Grynberg, M., Kaminska, J., Rzepnikowska, W., Urbanek, A., Zoladek, T.   +6 more
core   +2 more sources

SNX27:Retromer:ESCPE-1-mediated early endosomal tubulation impacts cytomegalovirus replication

Frontiers in Cellular and Infection Microbiology
Introduction Cytomegaloviruses (CMVs) extensively reorganize the membrane system of the cell and establish a new structure as large as the cell nucleus called the assembly compartment (AC).
Igor Štimac, M. Marcelić, Barbara Radić, Ivona Viduka, Gordana Blagojević Zagorac, Silvija Lukanović Jurić, Carmen Rožmanić, M. Messerle, I. Brizić, P. Lučin, Hana Mahmutefendić Lučin   +10 more
semanticscholar   +1 more source

The Retromer Complex: From Genesis to Revelations

Trends in Biochemical Sciences, 2021
The retromer complex has a well-established role in endosomal protein sorting, being necessary for maintaining the dynamic localisation of hundreds of membrane proteins that traverse the endocytic system. Retromer function and dysfunction is linked with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, and many pathogens, both ...
openaire   +3 more sources

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Molecular Neurodegeneration, 2020
Background The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS35 can regulate APP metabolism and
Jian-Guo Li, Jin Chiu, Mercy Ramanjulu, Benjamin E. Blass, Domenico Praticò   +4 more
doaj   +1 more source

dOCRL maintains immune cell quiescence in Drosophila by regulating endosomal traffic [PDF]

, 2017
Lowe Syndrome is a developmental disorder characterized by eye, kidney, and neurological pathologies, and is caused by mutations in the phosphatidylinositol-5-phosphatase OCRL.
A Faucherre, A Guha, A Legido, A Maminska, A Witsell, AA Lazareva, AK Satoh, AK Shia, AM Allmendinger, Avital A. Rodal, B Lemaitre, B Zhou, Benjamin H. Rosenfeld, BV Shravage, BZ Shilo, C Cauvin, C Savarin, CJ Noakes, CJ Zettervall, D Dambournet, D Stein, DA Kimbrell, E Beurel, E Kurucz, E Owusu-Ansah, F Oltrabella, G Emery, G Guglielmi, GD Gupta, GR Hammond, H Yang, HR Huang, IB Ramirez, IP Nezis, J Clasadonte, J Manaka, J Zhang, JC Hombria, JM Abrams, JQ Ni, JR van Weering, JW Wang, K Ben El Kadhi, K Ketel, K Koles, K Makhijani, Katherine S. Lehmann, KJ Venken, KS Erdmann, KS Gold, L Sun, M Crozatier, M Erta, M Mavrakis, M Vicinanza, M Yamamoto-Hino, MA De Matteis, ME Haberland, MG De Leo, MJ Williams, MM Davis, MR Schmid, N Luo, N Matova, NC Franc, Norbert Perrimon, P Zhang, PG Billcliff, R Choudhury, R Markus, R Markus, R Nandez, R Wubbolts, RJ Khadilkar, S Codeluppi, S Dunst, S Jean, S Minakhina, S Petraki, S Takats, SA Sinenko, Sarah A. Biber, Sean T. Sweeney, SF Soukup, SH Jung, SP Bothwell, Stephanie R. Heimler, Steven J. Del Signore, SW Brubaker, T Lin, Tania L. Eskin, TM Khuong, V Honti, V Honti, VI Korolchuk, W Mobius, Y Shen, ZB Mehta   +97 more
core   +3 more sources

BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers. [PDF]

, 2016
Endomembrane organelle maturation requires cargo delivery via fusion with membrane transport intermediates and recycling of fusion factors to their sites of origin.
Amanda Acosta-Ruiz, Anderson, Barlowe, Bennett, Boissy, Bonifacino, Bright, Brooks, Bultema, Bultema, Burgo, Burgo, Cai, Chen, Chiang, Cullinane, Cédric Delevoye, Danglot, Danglot, David J. Owen, Delevoye, Delevoye, Dell’Angelica, Dennis, Di Pietro, Domanska, Dorothy C. Bennett, Elena V. Sviderskaya, Fader, Fader, Gardner, Geoffrey G. Hesketh, Gerondopoulos, Ghiani, Gordon, Graça Raposo, Hesketh, Huang, Huizing, Ilse Hurbain, J. Paul Luzio, Jahn, Jani, Kent, Lane, Loftus, Lopes, Luzio, Marks, Martina, Martinez-Arca, Maryse Romao, McGough, Megan K. Dennis, Meng, Michael S. Marks, Mohrmann, Molino, Morita, Nazarian, Newell-Litwa, Nguyen, Nguyen, Orlow, Osanai, Philip S. Goff, Prekeris, Pryor, Pu, Richmond, Ryder, Salazar, Schäfer, Setty, Setty, Seward, Sitaram, Sitaram, Suzuki, Sviderskaya, Takeuchi, Tamura, Tamura, Theos, Thierry Galli, Vijayasaradhi, Wade, Wang, Wasmeier, Wassmer, Wei, Wei, Yatsu, Zhang   +93 more
core   +2 more sources

Regulation of the endosomal SNX27-retromer by OTULIN

Nature Communications, 2019
OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 ...
Aurelia Stangl, Paul R. Elliott, Adan Pinto-Fernandez, Sarah Bonham, Luke Harrison, Annalisa Schaub, Kerstin Kutzner, Kirstin Keusekotten, Paul T. Pfluger, Farid El Oualid, Benedikt M. Kessler, David Komander, Daniel Krappmann   +12 more
doaj   +1 more source