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HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs

open access: yes
Draper D   +6 more
europepmc   +1 more source
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Oxidation of retromer complex controls mitochondrial translation

Nature
Reactive oxygen species (ROS) underlie human pathologies including cancer and neurodegeneration1,2. However, the proteins that sense ROS levels and regulate their production through their cysteine residues remain ill defined. Here, using systematic base-editing and computational screens, we identify cysteines in VPS35, a member of the retromer ...
Junbing Zhang   +34 more
semanticscholar   +3 more sources

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