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Receptor Recycling by Retromer
Molecular and Cellular Biology, 2023The highly conserved retromer complex controls the fate of hundreds of receptors that pass through the endolysosomal system and is a central regulatory node for diverse metabolic programs. More than 20 years ago, retromer was discovered as an essential regulator of endosome-to-Golgi transport in yeast; since then, significant progress has been made to ...
Julian M. Carosi +3 more
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Recent Advances in Retromer Biology
Traffic, 2011The endosomal network is an organized array of intracellular, membranous compartments that function as sorting sites for endosomal and biosynthetic cargo. The fate of endocytic cargo is reliant upon interactions with a number of molecularly distinct sorting complexes, which tightly control the relationship between sorting of their respective cargo and ...
McGough, IJ, Cullen, PJ
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New Phytologist
In eukaryotes, the retromer complex plays a crucial role in the sorting and retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN).
Yunfei Long +14 more
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In eukaryotes, the retromer complex plays a crucial role in the sorting and retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN).
Yunfei Long +14 more
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A Novel Mammalian Retromer Component, Vps26B
Traffic, 2005The mammalian retromer protein complex, which consists of three proteins – Vps26, Vps29, and Vps35 – in association with members of the sorting nexin family of proteins, has been implicated in the trafficking of receptors and their ligands within the endosomal/lysosomal system of mammalian cells.
Kerr, Markus C. +7 more
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Trying to make sense of retromer
Trends in Plant Science, 2012Retromer is a cytosolic protein complex which binds to post-Golgi organelles involved in the trafficking of proteins to the lytic compartment of the cell. In non-plant organisms, retromer mediates the recycling of acid hydrolase receptors from early endosomal (EE) compartments.
David G, Robinson +5 more
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Recycle your receptors with retromer
Trends in Cell Biology, 2005Nature has always been efficient at saving energy and preventing waste. A good example of the thriftiness of nature is the recycling of receptors that mediate the transport of hydrolases to the lysosome in animal cells or to the vacuole in plants and fungi.
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2023
The regulated trafficking of receptors and their associated ligands through the mammalian endosomal system is a process fundamental to the maintenance of cellular homeostasis. Whilst a great deal is known about the mechanisms by which receptors are internalised at the plasma membrane, the molecular machinery involved in their sorting, segregation and ...
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The regulated trafficking of receptors and their associated ligands through the mammalian endosomal system is a process fundamental to the maintenance of cellular homeostasis. Whilst a great deal is known about the mechanisms by which receptors are internalised at the plasma membrane, the molecular machinery involved in their sorting, segregation and ...
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Proceedings of the National Academy of Sciences of the United States of America
The activation of the vesicular trafficking system, including endosomal recycling and extracellular vesicle (EV) release, represents an adaptive mechanism in cancer cells to counteract cellular stress or necroptotic death signals, which hampers cancer ...
Yang Wang +11 more
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The activation of the vesicular trafficking system, including endosomal recycling and extracellular vesicle (EV) release, represents an adaptive mechanism in cancer cells to counteract cellular stress or necroptotic death signals, which hampers cancer ...
Yang Wang +11 more
semanticscholar +1 more source
British Journal of Pharmacology
The abnormal accumulation of amyloid‐β (Aβ) in the brain is a characteristic pathological change observed in patients with Alzheimer's disease (AD). Microglial phagocytosis, dependent on recycling through the retromer complex and cell membrane‐bound ...
Yue Zhang +13 more
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The abnormal accumulation of amyloid‐β (Aβ) in the brain is a characteristic pathological change observed in patients with Alzheimer's disease (AD). Microglial phagocytosis, dependent on recycling through the retromer complex and cell membrane‐bound ...
Yue Zhang +13 more
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Retromer and sorting nexins in endosomal sorting
Biochemical Society Transactions, 2015The evolutionarily conserved endosomal retromer complex rescues transmembrane proteins from the lysosomal degradative pathway and facilitates their recycling to other cellular compartments. Retromer functions in conjunction with numerous associated proteins, including select members of the sorting nexin (SNX) family.
Matthew, Gallon, Peter J, Cullen
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