Results 241 to 250 of about 11,758 (252)

The Role of Retromer in Alzheimer’s Disease

Molecular Neurobiology, 2015
The retromer complex is an important component of the endosomal protein sorting machinery and mediates protein cargoes from endosomes to the trans-Golgi network (TGN) by retrograde pathway or to the cell surface through recycling pathway. Studies show that retromer and its receptors can make amyloid precursor protein (APP)/β-site APP-cleaving enzyme 1 (
Qiu-Yue, Zhang, Meng-Shan, Tan, Jin-Tai, Yu, Lan, Tan   +3 more
openaire   +2 more sources

Retromer in Polarized Protein Transport

2016
Retromer is an evolutionary conserved protein complex required for endosome-to-Golgi retrieval of receptors for lysosomal hydrolases. It is constituted by a heterotrimer encoded by the vacuolar protein sorting (VPS) gene products Vps26, Vps35, and Vps29, which selects cargo, and a dimer of phosphoinositide-binding sorting nexins, which deforms the ...
openaire   +2 more sources

Vacuolar recruitment of retromer by a SNARE complex enables infection‐related trafficking in rice blast

New Phytologist
The retromer complex is a conserved sorting machinery that maintains cellular protein homeostasis by transporting vesicles containing cargo proteins to defined destinations. It is known to sort proteins at the vacuole membranes for retrograde trafficking,
Xin Chen, Jiexiong Hu, Haoming Zhong, Qiuqiu Wu, Zhenyu Fang, Yan Cai, Panpan Huang, Y. S. Abubakar, Jie Zhou, Naweed I. Naqvi, Zonghua Wang, Wenhui Zheng   +11 more
semanticscholar   +1 more source

Retromer and sorting nexins in development

Frontiers in Bioscience, 2007
Trafficking and signaling processes involve common molecular components. The machinery that controls intracellular trafficking is vital in ensuring that signaling mechanisms take place correctly. An illustrative example of this relationship is the sustained signaling of endocytosed membrane receptors, such as receptor Tyr kinases and G-protein coupled ...
openaire   +2 more sources

Honokiol enhances the sensitivity of cetuximab in KRASG13D mutant colorectal cancer through destroying SNX3-retromer complex

Theranostics
Rationale: the proto-oncogene KRAS is frequently mutated in colorectal cancer (CRC), leading to inherent resistance against monoclonal antibodies targeting the epidermal growth factor receptor (EGFR), such as cetuximab.

semanticscholar   +1 more source

Retromer-Mediated Protein Sorting and Vesicular Trafficking

Journal of Genetics and Genomics, 2016
Retromer is an evolutionarily conserved multimeric protein complex that mediates intracellular transport of various vesicular cargoes and functions in a wide variety of cellular processes including polarized trafficking, developmental signaling and lysosome biogenesis.
openaire   +2 more sources

The retromer complex

Advances in Enzyme Regulation, 2010
Naomi, Attar, Peter J, Cullen
openaire   +2 more sources

VPS35/Retromer-dependent MT1-MMP regulation confers melanoma metastasis

bioRxiv
Qinggang Hao, Yan Bai, Ruiqi Guan, Rui Dong, Weiyu Bai, Hayam Hamdy, Liqiong Wang, Mingyao Meng, Yan Sun, Junling Shen, Jianwei Sun   +10 more
semanticscholar   +1 more source

Separation of powers: A key feature underlying the neuroprotective role of Retromer in age-related neurodegenerative disease?

Current Opinion in Cell Biology
Brett M. Collins, P. J. Cullen
semanticscholar   +1 more source

Retromer

2011
openaire   +1 more source