Results 81 to 90 of about 9,787 (196)
γ-secretase facilitates retromer-mediated retrograde transport.
J Cell SciABSTRACT Retromer mediates retrograde transport of protein cargoes from endosomes to the trans-Golgi network (TGN). γ-secretase is a protease that cleaves the transmembrane domain of its target proteins. Although retromer can form a stable complex with γ-secretase, the functional consequences of this interaction are not known.
Takeo Y, Crite M, Mehmood K, DiMaio D.
europepmc +5 more sources
Endosomal Recycling Defects and Neurodevelopmental Disorders
Cells, 2022 The quality and quantity of membrane proteins are precisely and dynamically maintained through an endosomal recycling process. This endosomal recycling is executed by two protein complexes: retromer and recently identified retriever.
Shinji Saitoh
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background The cerebrospinal fluid alpha‐synuclein seed amplification assay (CSFasynSAA) detects alpha‐synuclein aggregation in over 90% of individuals with sporadic PD (sPD). However, the clinical characteristics of sPD with negative CSFasynSAA remain undefined.
Sarah M. Brooker +30 more
wiley +1 more source
Retromer: A Master Conductor of Endosome Sorting [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 The endosomal network comprises an interconnected network of membranous compartments whose primary function is to receive, dissociate, and sort cargo that originates from the plasma membrane and the biosynthetic pathway. A major challenge in cell biology is to achieve a thorough molecular description of how this network operates, and in so doing, how ...
Burd, Christopher, Cullen, Peter J.
openaire +3 more sources
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration [PDF]
, 2014 Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD).
A. Fiser +38 more
core +5 more sources
Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval [PDF]
, 2018 The AP-5 adaptor protein complex is presumed to function in membrane traffic, but so far nothing is known about its pathway or its cargo. We have used CRISPR-Cas9 to knock out the AP-5 ζ subunit gene, AP5Z1, in HeLa cells, and then analysed the phenotype
Antrobus, Robin +4 more
core +3 more sources
The FEBS Journal, EarlyView.TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior +5 more
wiley +1 more source
VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin. [PDF]
, 2015 Mutations in VPS35 (PARK17) cause autosomal dominant, late onset Parkinson's disease (PD). VPS35 forms a core component of the retromer complex that mediates the retrieval of membrane proteins from endosomes back to either the Golgi or plasma membrane ...
Alexander J. Whitworth +3 more
core +3 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT High temperature has posed significant challenges to global agriculture, markedly leading to reduced fertility and yield losses in tomato (Solanum lycopersicum). Therefore, thermotolerance‐conferring genes and loci are needed to further improve cultivated tomatoes.
Xiaolin Geng +9 more
wiley +1 more source
Correction to "From Mitochondria to Immunity: The Emerging Roles of Mitochondria-Derived Vesicles and Small Extracellular Vesicles in Cellular Communication and Disease". [PDF]
J Extracell VesiclesJournal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
europepmc +2 more sources