Results 81 to 90 of about 11,758 (252)
Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. [PDF]
, 2015 Notch signaling is a major regulator of cell fate, proliferation, and differentiation. Like other signaling pathways, its activity is strongly influenced by intracellular trafficking.
Bray, Sarah J +4 more
core +1 more source
Retromer Dysfunction and Neurodegenerative Disease [PDF]
Current Genomics, 2018 In recent years, genomic, animal and cell biology studies have implicated deficiencies in retromer-mediated trafficking of proteins in an increasing number of neurodegenerative diseases including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Frontotemporal Lobar Degener-ation (FTLD).
openaire +2 more sources
The retromer complex in development and disease [PDF]
Development, 2015 The retromer complex is a multimeric protein complex involved in recycling proteins from endosomes to the trans-Golgi network or plasma membrane. It thus regulates the abundance and subcellular distribution of its cargo within cells. Studies using model organisms show that the retromer complex is involved in specific developmental processes.
Shiuan, Wang, Hugo J, Bellen
openaire +2 more sources
Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. [PDF]
PLoS ONE, 2013 In C. elegans and Drosophila, retromer mediated retrograde transport of Wntless (Wls) from endosomes to the trans-Golgi network (TGN) is required for Wnt secretion.
Reinoud E A de Groot +5 more
doaj +1 more source
Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval [PDF]
, 2018 The AP-5 adaptor protein complex is presumed to function in membrane traffic, but so far nothing is known about its pathway or its cargo. We have used CRISPR-Cas9 to knock out the AP-5 ζ subunit gene, AP5Z1, in HeLa cells, and then analysed the phenotype
Antrobus, Robin +4 more
core +3 more sources
Frontiers in Cardiovascular Medicine, 2021 Lysosomal dysfunction has been found in many pathological conditions, and methods to improve lysosomal function have been reported to be protective against infarcted hearts.
Lin Cui +11 more
doaj +1 more source
New Phytologist, EarlyView.Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada +9 more
wiley +1 more source
Membrane transport: Retromer to the rescue [PDF]
Current Biology, 2001 Genetic analysis in yeast has led to the discovery of a complex that retrieves proteins selectively from the prevacuolar compartment and transports them to the Golgi. Orthologs of these proteins in mammalian cells are likely to play a similar role but their cargoes are yet to be identified.
openaire +2 more sources
Retromer dysfunction at the nexus of tauopathies
Cell Death & Differentiation, 2021 Tauopathies define a broad range of neurodegenerative diseases that encompass pathological aggregation of the microtubule-associated protein tau. Although tau aggregation is a central feature of these diseases, their underlying pathobiology is remarkably heterogeneous at the molecular level.
Julian M. Carosi +3 more
openaire +5 more sources
HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1 [PDF]
, 2019 An estimated 10–20 million people worldwide are infected with human T cell leukemia virus type 1 (HTLV-1), with endemic areas of infection in Japan, Australia, the Caribbean, and Africa.
Al-Saleem, Jacob +6 more
core +3 more sources