Results 91 to 100 of about 50,973 (340)

Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing [PDF]

, 2014
Retrotransposons constitute a major source of genetic variation, and somatic retrotransposon insertions have been reported in cancer. Here, we applied TranspoSeq, a computational framework that identifies retrotransposon insertions from sequencing data ...
Getz, Gad, Helman, Elena, Lawrence, Michael S., Meyerson, Matthew L., Sougnez, Carrie, Stewart, Chip   +5 more
core   +1 more source

High oxygen tension increases global methylation in bovine 4-cell embryos and blastocysts but does not affect general retrotransposon expression.

Reproduction, Fertility and Development, 2016
Retrotransposons are transposable elements that insert extra copies of themselves throughout the genome via an RNA intermediate using a 'copy and paste' mechanism.
Wenwen Li, K. Goossens, M. Van Poucke, K. Forier, K. Braeckmans, A. Van Soom, L. Peelman   +6 more
semanticscholar   +1 more source

The diversity of LTR retrotransposons.

Genome biology, 2004
Eukaryotic genomes are full of long terminal repeat (LTR) retrotransposons. Although most LTR retrotransposons have common structural features and encode similar genes, there is nonetheless considerable diversity in their genomic organization, reflecting the different strategies they use to proliferate within the genomes of their hosts.
Daniel F. Voytas, Xiang Gao, Ericka R. Havecker   +2 more
openaire   +3 more sources

Endogenous Retroelement Activation is Implicated in Interferon‐α Production and Anti–Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Endogenous retroelements (EREs) stimulate type 1 interferon (IFN‐I) production but have not been explored as potential interferonogenic triggers in rheumatoid arthritis (RA). We investigated ERE expression in early RA (eRA), a period in which IFN‐I levels are increased.
Faye A. H. Cooles, Gemma Vidal Pedrola, Najib Naamane, Arthur G. Pratt, Ben Barron‐Millar, Amy E. Anderson, Catharien M. U. Hilkens, John Casement, Vincent Bondet, Darragh Duffy, Fan Zhang, Ruchi Shukla, John D. Isaacs   +12 more
wiley   +1 more source

CARE1, a TY3-gypsy long terminal repeat retrotransposon in the food legume chickpea (Cicer arietinum L) [PDF]

, 2007
We report a novel Ty3-gypsy long terminal repeat retrotransposon CARE1 (_Cicer arietinum_ retro-element 1) in chickpea. This 5920-bp AT-rich (63%) element carries 723-bp 5' and 897-bp 3' LTRs respectively flanking an internal region of 4300-bp.
Kailash C. Upadhyaya, Manoj D. R. Rajput
core   +1 more source

Retrotransposons and Diabetes Mellitus

Epigenomes
Retrotransposons are invasive genetic elements, which replicate by copying and pasting themselves throughout the genome in a process called retrotransposition. The most abundant retrotransposons by number in the human genome are Alu and LINE-1 elements, which comprise approximately 40% of the human genome.
Andromachi Katsanou, Charilaos Kostoulas, Evangelos Liberopoulos, Agathocles Tsatsoulis, Ioannis Georgiou, Stelios Tigas   +5 more
openaire   +3 more sources

CRISPR deletion of a SINE-VNTR-Alu (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the MAPT locus

Frontiers in Neurology, 2023
BackgroundSINE-VNTR-Alu (SVA) retrotransposons are hominid-specific elements which have been shown to play important roles in processes such as chromatin structure remodelling and regulation of gene expression demonstrating that these repetitive elements
Alexander Fröhlich, Alexander Fröhlich, Lauren S. Hughes, Ben Middlehurst, Abigail L. Pfaff, Abigail L. Pfaff, Vivien J. Bubb, Sulev Koks, Sulev Koks, John P. Quinn   +9 more
doaj   +1 more source

Heterogeneity in Ty1-copia group of retroelements in chickpea (Cicer arietinum) genome [PDF]

, 2007
Retrotransposons constitute a major fraction of plant genomes and these elements may have played a significant role in evolution and sequence organization of genomes.
Kailash C. Upadhyaya, Manoj K. Rajput
core   +1 more source

High-frequency recombination between members of an LTR retrotransposon family during transposition bursts

Nature Communications, 2017
Retrotransposons containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes. The timing of past transposition can be estimated by quantifying the accumulation of mutations in initially identical LTRs.
D. H. Sánchez, Hervé Gaubert, Hajk-Georg Drost, N. Zabet, J. Paszkowski   +4 more
semanticscholar   +1 more source

Evolution of Centromeric Retrotransposons in Grasses [PDF]

Genome Biology and Evolution, 2014
Centromeric retrotransposons (CRs) constitute a family of plant retroelements, some of which have the ability to target their insertion almost exclusively to the functional centromeres. Our exhaustive analysis of CR family members in four grass genomes revealed not only horizontal transfer (HT) of CR elements between the oryzoid and panicoid grass ...
Anupma Sharma, Gernot G. Presting
openaire   +3 more sources