Results 101 to 110 of about 32,942 (307)

Retrotransposons and the Eternal Leaves

, 2012
The resurrection plant Craterostigma plantagineum can tolerate up to 96% loss of its relative water content and recover within hours after rehydration. In callus tissue desiccation tolerance is induced by pre-incubation with Abscisic acid (ABA). In callus and plant ABA treatment and dehydration induce a set of dehydration-responsive genes.
openaire   +4 more sources

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells

Aging Cell, EarlyView.
Expression of HIRA in embryonic melanoblasts is required for proper epigenetic programing and lineage differentiation. Although HIRA deficiency results in a mild phenotype at birth and young adulthood, the melanocytic lineage is sensitive to proliferative challenge, prone to loss of stem cells and dramatically accelerated hair greying in later life ...
Farah Jaber‐Hijazi, Rouven Arnold, Karthic Swaminathan, Kathryn Gilroy, Alexander T. Wenzel, Anthony Lagnado, Kristina Kirschner, Neil Robertson, Claire Reid, Neil Fullarton, Jeff Pawlikowski, Taranjit Singh Rai, Ian Baranyk, Christina Huan Shi, Kevin Y. Yip, Karen Blyth, Jill P. Mesirov, Melissa L. Harris, João F. Passos, Laura M. Machesky, Peter D. Adams   +20 more
wiley   +1 more source

Pivotal Impacts of Retrotransposon Based Invasive RNAs on Evolution

Frontiers in Microbiology, 2017
RNAs have long been described as the mediators of gene expression; they play a vital role in the structure and function of cellular complexes. Although the role of RNAs in the prokaryotes is mainly confined to these basic functions, the effects of these ...
Laleh Habibi, Hamzeh Salmani
doaj   +1 more source

Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma

Nature Network Boston, 2015
Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed after the disease has metastasized; it is among the most lethal forms of cancer. We recently described aberrant expression of an open reading frame 1 protein, ORF1p, encoded by long ...
N. Rodić, Jared P Steranka, Alvin P. Makohon-Moore, Allison Moyer, Peilin Shen, Reema Sharma, Z. Kohutek, C. Huang, Daniel Ahn, P. Mita, Martin S. Taylor, Norman J Barker, R. Hruban, C. Iacobuzio-Donahue, J. Boeke, K. Burns   +15 more
semanticscholar   +1 more source

Age and Sex Effects on Blood Retrotransposable Element Expression Levels: Findings From the Population‐Based Rhineland Study

Aging Cell, EarlyView.
Retrotransposable element (RTE) expression increases with chronological and biological age and is negatively associated with heterochromatin regulators. Moreover, RTE expression shows sex‐specific differences, with higher levels in men and enrichment for immune‐related pathways.
Valentina Talevi, Hang‐Mao Lee, Dan Liu, Marc D. Beyer, Paolo Salomoni, Monique M. B. Breteler, N. Ahmad Aziz   +6 more
wiley   +1 more source

Primate specific retrotransposons, SVAs, in the evolution of networks that alter brain function [PDF]

arXiv, 2016
The hominid-specific non-LTR retrotransposon termed SINE VNTR Alu (SVA) is the youngest of the transposable elements in the human genome. The propagation of the most ancient SVA type A took place about thirteen millions years ago ago, and the youngest SVA types appeared in the human genome after the chimpanzee divergence. Functional enrichment analysis
arxiv  

How a Retrotransposon Exploits the Plant's Heat Stress Response for Its Activation

PLoS Genetics, 2014
Retrotransposons are major components of plant and animal genomes. They amplify by reverse transcription and reintegration into the host genome but their activity is usually epigenetically silenced.
V. Čavrak, Nicole Lettner, Suraj Jamge, Agata Kosarewicz, Laura Bayer, O. Mittelsten Scheid   +5 more
semanticscholar   +1 more source

Skipper, an LTR retrotransposon of Dictyostelium [PDF]

Nucleic Acids Research, 1998
The complete sequence of a retrotransposon from Dictyostelium discoideum , named skipper , was obtained from cDNA and genomic clones. The sequence of a nearly full-length skipper cDNA was similar to that of three other partially sequenced cDNAs. The corresponding retrotransposon is represented in approximately 15-20 copies and is abundantly transcribed.
Jef D. Boeke, Gerald Schumann, David H. Klatte, Ping Leng, Theodore L. Steck   +4 more
openaire   +3 more sources

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Links between human LINE-1 retrotransposons and hepatitis virus-related hepatocellular carcinoma

Frontiers in Chemistry, 2016
Hepatocellular carcinoma (HCC) accounts for approximately 80% of liver cancers, the third most frequent cause of cancer mortality. The most prevalent risk factors for HCC are infections by hepatitis B or hepatitis C virus. Findings suggest that hepatitis
Tomoyuki eHonda, Tomoyuki eHonda
doaj   +1 more source