Retroelements versus APOBEC3 family members: No great escape from the magnificent seven
Frontiers in Microbiology, 2012 Retroelements comprise a large and successful family of transposable genetic elements that, through intensive infiltration, have shaped the genomes of humans and other mammals over millions of years.
Kenzo Tokunaga
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Association between Human Endogenous Retrovirus K gene expression and breast cancer [PDF]
Cellular, Molecular and Biomedical Reports, 2021 Breast cancer is one of the most common cancers known, and it is also a significant cause of death in women. If breast cancer is diagnosed in the early stages of the disease and treated appropriately, we can see an increase in life expectancy for more ...
Masoud Tourang +3 more
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Prospects for the use of statins in antiviral therapy [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses.
Mustafin R.N.
doaj +1 more source
Involvement of retroelements in the autoimmune response in humans
Exploration of Medicine, 2022 Retroelements are mobile genomic components requiring an RNA intermediate which is reverse-transcribed into complementary DNA for transposition. Human genome contains a vast amount of retroelements including retrotransposons and endogenous retroviruses ...
Sezer Okay
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Large-scale transcriptome analysis of retroelements in the migratory locust, Locusta migratoria. [PDF]
PLoS ONE, 2012 BackgroundRetroelements can successfully colonize eukaryotic genome through RNA-mediated transposition, and are considered to be some of the major mediators of genome size.
Feng Jiang +4 more
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Role of retroelements in the development of COVID-19 neurological consequences
Russian Open Medical Journal, 2022 Retroelements play a key role in brain functioning in humans and other animals, since they represent dynamic regulatory elements controlling the expression of specific neuron types.
Rustam N. Mustafin +3 more
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Eco-evolutionary significance of domesticated retroelements in microbial genomes
Mobile DNA, 2022 Since the first discovery of reverse transcriptase in bacteria, and later in archaea, bacterial and archaeal retroelements have been defined by their common enzyme that coordinates diverse functions.
Blair G. Paul, A. Murat Eren
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LINE-1 and SINE-B1 mapping and genome diversification in Proechimys species (Rodentia: Echimyidae)
Life Science Alliance, 2022 Signal distribution of L1 and B1 among chromosomes in five species of Proechimys may represent a strong indication of their role in karyotype diversity of this speciose Neotropical rodent.
Simone Cardoso Soares +6 more
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Does selection against transcriptional interference shape retroelement-free regions in mammalian genomes? [PDF]
PLoS ONE, 2008 BACKGROUND: Eukaryotic genomes are scattered with retroelements that proliferate through retrotransposition. Although retroelements make up around 40 percent of the human genome, large regions are found to be completely devoid of retroelements.
Tobias Mourier, Eske Willerslev
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The evidence for increased L1 activity in the site of human adult brain neurogenesis. [PDF]
PLoS ONE, 2015 Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention.
Alexey A Kurnosov +9 more
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