Results 131 to 140 of about 55,792 (268)

In Vivo Maternal Haploid Induction by Disrupting KOKOPELLI in Medicago truncatula

open access: yes
Plant Biotechnology Journal, EarlyView.
Na Wang   +8 more
wiley   +1 more source

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So   +7 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, Volume 20, Issue 3, Page 709-726, March 2026.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Mutations in retrotransposon AtCOPIA4 compromises resistance to Hyaloperonospora parasitica in Arabidopsis thaliana

open access: yesGenetics and Molecular Biology, 2010
Retrotransposons (RTEs) are a principal component of most eukaryotic genomes, representing 50%-80% of some grass genomes. RTE sequences have been shown to be preferentially present in disease resistance gene clusters in plants.
Yi-Hong Wang, James T. Warren Jr.
doaj  

Activity and Silencing of Transposable Elements in C. elegans

open access: yesDNA
Since the discovery of transposable elements (TEs) in maize in the 1940s by Barbara McClintock transposable elements have been described as junk, as selfish elements with no benefit to the host, and more recently as major determinants of genome structure
Sylvia E. J. Fischer
doaj   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

open access: yesAdvanced Science, Volume 13, Issue 17, 23 March 2026.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan   +21 more
wiley   +1 more source

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu   +5 more
wiley   +1 more source

Translocation of a 190-kb mitochondrial fragment into rice chromosome 12 followed by the integration of four retrotransposons

open access: yesInternational Journal of Biological Sciences, 2005
A 190-kb mitochondrial DNA sequence interrupted by seven foreign DNA segments was identified in rice chromosome 12. This fragment is the largest mitochondrial fragment translocated into the rice nuclear genome.
doaj  

Mild Photoperiod and Temperature Fluctuations Elicit Tissue‐Specific DNA Methylation Changes in Arabidopsis

open access: yes
Plant, Cell &Environment, EarlyView.
Ji Hoon Rhee   +4 more
wiley   +1 more source

Transposon Ecology and the Octopus Genome

open access: yesBioEssays, Volume 48, Issue 3, March 2026.
Transposable elements (TEs) are mobile strands of DNA prevalent in octopus genomes. TE activity in the octopus brain might reflect an organism‐beneficial role in cognition; or could be a deleterious byproduct of TE parasitism. Viewing TEs from a genome‐ecology perspective generates novel predictions about differential expression levels across “genomic ...
Stefan Linquist   +5 more
wiley   +1 more source

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