Results 131 to 140 of about 50,973 (340)
Aging Cell, EarlyView.Autophagy regulates ovarian reserve, with Cathepsin B playing a critical role in aging. Inhibition of Cathepsin B increases follicle count, enhances IGF1R–AKT–mTOR signaling and improves mitochondrial function without compromising fertility. This conserved mechanism suggests potential therapeutic strategies to delay ovarian aging and sustain fertility,
Aradhana Mohanty +8 more
wiley +1 more source
Primate specific retrotransposons, SVAs, in the evolution of networks that alter brain function [PDF]
arXiv, 2016 The hominid-specific non-LTR retrotransposon termed SINE VNTR Alu (SVA) is the youngest of the transposable elements in the human genome. The propagation of the most ancient SVA type A took place about thirteen millions years ago ago, and the youngest SVA types appeared in the human genome after the chimpanzee divergence. Functional enrichment analysis
arxiv
Genomic resource development for a diploid mint: Mentha longifolia [PDF]
, 2010 This research project aimed to develop genomic resources needed to enable construction of a genetic linkage map of the diploid mint species Mentha longifolia.
Hadadian, Zahra
core +1 more source
Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma
Nature Network Boston, 2015 Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed after the disease has metastasized; it is among the most lethal forms of cancer. We recently described aberrant expression of an open reading frame 1 protein, ORF1p, encoded by long ...
N. Rodić +15 more
semanticscholar +1 more source
Skipper, an LTR retrotransposon of Dictyostelium [PDF]
Nucleic Acids Research, 1998 The complete sequence of a retrotransposon from Dictyostelium discoideum , named skipper , was obtained from cDNA and genomic clones. The sequence of a nearly full-length skipper cDNA was similar to that of three other partially sequenced cDNAs. The corresponding retrotransposon is represented in approximately 15-20 copies and is abundantly transcribed.
Jef D. Boeke +4 more
openaire +3 more sources
Aging Cell, EarlyView.Retrotransposable element (RTE) expression increases with chronological and biological age and is negatively associated with heterochromatin regulators. Moreover, RTE expression shows sex‐specific differences, with higher levels in men and enrichment for immune‐related pathways.
Valentina Talevi +6 more
wiley +1 more source
Nucleic Acids Research, 2017 LTR retrotransposons are repetitive DNA elements comprising ∼10% of the human genome. However, LTR sequences are disproportionately present in human long, non-coding RNAs (lncRNAs).
Tianxiang Hu +7 more
semanticscholar +1 more source
L1 Retrotransposons in Human Cancers [PDF]
BioMed Research International, 2006 Retrotransposons like L1 are silenced in somatic cells by a variety of mechanisms acting at different levels. Protective mechanisms include DNA methylation and packaging into inactive chromatin to suppress transcription and prevent recombination, potentially supported by cytidine deaminase editing of RNA.
openaire +2 more sources
British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
VirusesLTR-retrotransposons are transposable elements characterized by the presence of long terminal repeats (LTRs) directly flanking an internal coding region. They share genome organization and replication strategies with retroviruses. Steamer-like Element-1 (
Leandro Fernández-García +5 more
doaj +1 more source