Results 151 to 160 of about 67,814 (281)

Systemic LINE‐1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS‐STING Pathway in Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Plasma extracellular vesicle‐derived LINE‐1 RNA increases with age and crosses the blood–brain barrier to activate microglial cGAS‐STING signaling, driving neuroinflammation and cognitive decline. Inhibition of LINE‐1 reverse transcription or STING signaling ameliorates these aging‐related deficits.
Shuyi Yu, Qian Cheng, Qian Yu, Zhikang Cui, Hang Chen, Shuang Wu, Yan Jin, Yunshan Wang, Ming Li, Zhiming Lu   +9 more
wiley   +1 more source

Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis

Biomolecules
PIWI-interacting RNAs (piRNAs) are small noncoding RNAs that are almost exclusively expressed in germ cells to silence harmful transposons to maintain genome stability. PIWIL4 is guided by its associated piRNAs to transposable elements, where it recruits
Xiayu Wang, Qian Du, Wanqian Li, Zhongyu Zou, Chikun Wang, Yan Zhou, Zhibin Hu, Yayun Gu, Feng Li   +8 more
doaj   +1 more source

A Bioinformatics Approach for Detecting Repetitive Nested Motifs using Pattern Matching [PDF]

, 2016
The identification of nested motifs in genomic sequences is a complex computational problem. The detection of these patterns is important to allow discovery of transposable element (TE) insertions, incomplete reverse transcripts, deletions, and/or ...
Carballido, Jessica Andrea, Echenique, Carmen Viviana, Garbus, Ingrid, Ponzoni, Ignacio, Romero, José Rodolfo   +4 more
core  

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, Volume 183, Issue 1, Page 24-39, January 2026.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

FAM20C Modulates Neuronal Differentiation in Hypoxic–Ischemic Brain Damage via KAP1 Phosphorylation and LINE1 RNA m6A‐Dependent H3K9me3 Regulation

Cell Proliferation, Volume 59, Issue 1, January 2026.
FAM20C regulates the composition of the YTHDC1‐NCL‐KAP1‐LINE1 RNAs complex, thereby affecting neuronal differentiation in hypoxic–ischemic brain damage (HIBD). ABSTRACT Neurodevelopmental impairment due to hypoxic–ischemic brain damage (HIBD) lacks effective biomarkers and therapeutic targets.
Chen‐xi Feng, Mei Wang, Gen Li, Si‐jia Chu, Di Wu, Xiao‐han Hu, Li‐xiao Xu, Mei Li, Xing Feng   +8 more
wiley   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Cleomaceae: diversity and potential of a model family for studies on the evolution of photosynthesis

Plant Biology, Volume 28, Issue 1, Page 6-17, January 2026.
The Cleomaceae family integrates floral diversity, physiological plasticity, and the evolution of C4 photosynthesis, serving as an important model to investigate plant adaptation and evolutionary innovation. Abstract Understanding the physiological and molecular mechanisms by which plants adapt to environmental factors is essential for improving crop ...
P. Falquetto‐Gomes, D. F. Parma, J. Souza‐Isabel, W. E. B. Barrios, A. P. M. Weber, W. L. Araújo, A. Nunes‐Nesi   +6 more
wiley   +1 more source

Retrotransposon Tto1: functional analysis and engineering for insertional mutagenesis [PDF]

, 2011
Retrotransposons are genomic parasites activated by stress conditions that can be seriously detrimental for their host. In this work I demonstrate that Tto1, a typical plant LTR retrotransposon with insertion preference into genes can be turned into a ...
Tramontano, Andrea, Tramontano, Andrea, Tramontano, Andrea   +2 more
core  

Translocation of a 190-kb mitochondrial fragment into rice chromosome 12 followed by the integration of four retrotransposons

International Journal of Biological Sciences, 2005
A 190-kb mitochondrial DNA sequence interrupted by seven foreign DNA segments was identified in rice chromosome 12. This fragment is the largest mitochondrial fragment translocated into the rice nuclear genome.
doaj  

Mutations in retrotransposon AtCOPIA4 compromises resistance to Hyaloperonospora parasitica in Arabidopsis thaliana

Genetics and Molecular Biology, 2010
Retrotransposons (RTEs) are a principal component of most eukaryotic genomes, representing 50%-80% of some grass genomes. RTE sequences have been shown to be preferentially present in disease resistance gene clusters in plants.
Yi-Hong Wang, James T. Warren Jr.
doaj