Results 51 to 60 of about 55,792 (268)

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Epigenetic reactivation of LINE‐1 retrotransposon disrupts NuRD corepressor functions and induces oncogenic transformation in human bronchial epithelial cells

Molecular Oncology, 2018
Long interspersed nuclear element‐1 (LINE‐1 or L1) reactivation is linked to poor prognosis in non‐small‐cell lung carcinoma (NSCLC), but the molecular bases of this response remain largely unknown.
Pasano Bojang Jr., Kenneth S. Ramos
doaj   +1 more source

On the move

eLife, 2018
The mechanisms by which a retrotransposon called LINE-1 duplicates itself and spreads through the human genome are becoming clearer.
Sandra L Martin
doaj   +1 more source

Intragenic L1 Insertion: One Possibility of Brain Disorder

Life, 2022
Long interspersed nuclear element 1 (LINE1, L1) is a retrotransposon comprising ~17% of the human genome. A subset of L1s maintains the potential to mobilize and alter the genomic landscape, consequently contributing to the change in genome integrity and
Ji-Hoon Son, Hyunsu Do, Jinju Han
doaj   +1 more source

Heterogeneity in Ty1-copia group of retroelements in chickpea (Cicer arietinum) genome [PDF]

, 2007
Retrotransposons constitute a major fraction of plant genomes and these elements may have played a significant role in evolution and sequence organization of genomes.
Kailash C. Upadhyaya, Manoj K. Rajput
core   +1 more source

Transcriptome Analyses of Tumor-Adjacent Somatic Tissues Reveal Genes Co-Expressed with Transposable Elements [PDF]

, 2019
Background: Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells.
Alberto, Adrian, Chung, Micky, Churchill, Daphnie, Clymer, Cody, Han, Mira V., Jonaid, G. M., Navarro Leija, Omar, Quinton, Sophia, Ross, Austin, Sexton, Corinne E.   +9 more
core   +2 more sources

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Comparing Two Varieties of Blood Orange: A Differential Methylation Region Within the Specific Encoding Sequence of a Retrotransposon Adjacent to the Ruby Locus

Horticulturae
The blood orange arose from the insertion of a retrotransposon adjacent to the Ruby gene, an MYB-type transcriptional activator of anthocyanin production, as reported previously.
Jianhui Wang, Zhihong Li, Weiqing Guo, Zhihan Liu, Mingfu Xu, Yan Sun, Dayu Liu, Ying Chen   +7 more
doaj   +1 more source

Introns as Protective Buffers Against Transposable Elements Invasion During Genome Gigantism in a Newt. [PDF]

Genes Cells
In the giant Pleurodeles waltl genome, introns serve as “structural buffers,” absorbing transposable elements (TEs) to protect coding exons. While this enables “gene body inflation,” persistent TE accumulation eventually leads to transcriptional silencing and functional collapse, or “burst,” of the gene architecture.
Bou K, Agata K.
europepmc   +2 more sources

LTR-retrotransposons in R. exoculata and other crustaceans [PDF]

, 2013
Transposable elements are major constituents of eukaryote genomes and have a great impact on genome structure and stability. They can contribute to the genetic diversity and evolution of organisms. Knowledge of their distribution among several genomes is
Bonnivard, Eric, Donnart, Tifenn, Esnault, Caroline, Graça, Paula, Higuet, Dominique, Piednoël, Mathieu   +5 more
core   +1 more source