Retrotransposon life cycle and its impacts on cellular responses
RNA BiologyApproximately 45% of the human genome is comprised of transposable elements (TEs), also known as mobile genetic elements. However, their biological function remains largely unknown.
Ahmad Luqman-Fatah +4 more
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G3: Genes, Genomes, Genetics, 2017 Most ribosomal proteins in Saccharomyces cerevisiae are encoded by two paralogs that additively produce the optimal protein level for cell growth. Nonetheless, deleting one paralog of most ribosomal protein gene pairs results in a variety of phenotypes ...
Ryan J. Palumbo +3 more
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Humic acids protective activity against manganese induced LTR (long terminal repeat) retrotransposon polymorphism and genomic instability effects in Zea mays [PDF]
, 2016 Long terminal repeat (LTR) retrotransposon polymorphism and genomic instability are considered to be one of the most important rearranging mechanisms under environmental stress.
Agar, Guleray +4 more
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A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer
Genome Research, 2016 Although human LINE-1 (L1) elements are actively mobilized in many cancers, a role for somatic L1 retrotransposition in tumor initiation has not been conclusively demonstrated.
E. Scott +5 more
semanticscholar +1 more source
Mouse tafazzin is required for male germ cell meiosis and spermatogenesis [PDF]
, 2015 Barth syndrome is an X-linked mitochondrial disease, symptoms of which include neutropenia and cardiac myopathy. These symptoms are the most significant clinical consequences of a disease, which is increasingly recognised to have a variable presentation.
Bryson, S. +6 more
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Assessment of genetic diversity in Iranian confectionary sunflower (Helianthus annuus L.) populations using retrotransposon based IRAP markers [PDF]
مجله بیوتکنولوژی کشاورزی, 2014 Genetic diversity is necessary for plant breeders to obtain new cultivars either with high yield, better quality, more adapted to abiotic stress or more resistant to pest and pathogens. Retrotransposons are current component of plant genomes. Ubiquitous,
Ashkan Basir Niya +3 more
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Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
bioRxiv, 2016 Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks.
L. Krug +10 more
semanticscholar +1 more source
LTR-retrotransposons in R. exoculata and other crustaceans [PDF]
, 2013 Transposable elements are major constituents of eukaryote genomes and have a great impact on genome structure and stability. They can contribute to the genetic diversity and evolution of organisms. Knowledge of their distribution among several genomes is
Bonnivard, Eric +5 more
core +1 more source
Regulation of rice root development by a retrotransposon acting as a microRNA sponge
eLife, 2017 It is well documented that transposable elements (TEs) can regulate the expression of neighbouring genes. However, their ability to act in trans and influence ectopic loci has been reported rarely.
Jungnam Cho, J. Paszkowski
semanticscholar +1 more source
Current Opinion in Genetics & Development, 1992 In the decade since Ty elements were discovered, advocates have argued they could be used as a genetic entrée to elusive host-type functions required by retroviruses. However, the advent of the polymerase chain reaction, coupled with a boom in funding for human immunodeficiency virus research have moved retroviral research apace, raising questions as ...
openaire +4 more sources