Results 21 to 30 of about 122,151 (262)
Frontiers in Immunology, 2022 Human T-cell leukemia virus type 1 (HTLV-1) is the causative infectious agent of adult T-cell leukemia/lymphoma (ATL) and chronic neurological disease.
Victoria Maksimova +9 more
doaj +1 more source
Identification and characterization of a novel enhancer in the HTLV-1 proviral genome
Nature Communications, 2022 Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al.
Misaki Matsuo +16 more
doaj +1 more source
Antioxidants, 2023 Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in some elderly human T-cell leukemia virus (HTVL-1) carriers.
Piyanard Boonnate +2 more
doaj +1 more source
Expansion of a retrovirus lineage in the koala genome
, 2022 Retroviruses have left their legacy in host genomes over millions of years as endogenous retroviruses (ERVs), and their structure, diversity, and prevalence provide insights into the historical dynamics of retrovirus–host interactions.
Pettersson, Mats +12 more
core +1 more source
dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins
Angewandte Chemie, EarlyView.Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng +7 more
wiley +2 more sources
Viruses, 2015 Background: indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas.
Camila Cánepa +6 more
doaj +1 more source
HIV Env conserved element DNA vaccine alters immunodominance in macaques
Human Vaccines & Immunotherapeutics, 2017 Sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. HIV Env is a highly-glycosylated protein composed of ‘conserved’ and ‘variable’ regions.
Xintao Hu +12 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Cell entry and exit of porcine endogenous retrovirus A: receptors and release inhibitor [PDF]
, 2010 Following the discovery that porcine endogenous retrovirus (PERV) can infect human cells, the potential risk of a zoonotic infection by PERV has been a major obstacle in the xenotransplantation field.
Mattiuzzo, G.
core
Biomolecules, 2023 Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL). HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host antiviral immunity; however, 5–10% of carriers lose this balance and develop ATL.
Shingo Nakahata +4 more
doaj +1 more source