Results 41 to 50 of about 134,326 (264)

Retrovirus Restriction Factors [PDF]

Molecular Cell, 2004
A number of cellular genes have recently been identified that actively inhibit retrovirus replication and so protect cells from infection. The genes target many distinct steps in the viral life cycle: entry, viral DNA synthesis, intracellular movement of viral nucleic acids, and viral gene expression.
openaire   +2 more sources

Retrovirus maturation-an extraordinary structural transformation.

Current Opinion in Virology, 2016
Retroviruses such as HIV-1 assemble and bud from infected cells in an immature, non-infectious form. Subsequently, a series of proteolytic cleavages catalysed by the viral protease leads to a spectacular structural rearrangement of the viral particle ...
Simone Mattei, Florian K. M. Schur, J. Briggs   +2 more
semanticscholar   +1 more source

A novel hairless highly immunodeficient mice model optimized for in vivo imaging

Laboratory Animal Research
Background In vivo imaging is one of the analytical technologies that has been rapidly growing in demand in recent years to non-invasively observe the behavior of molecules such as genes and proteins in vivo and perform quantitative and qualitative ...
Kouki Matsuda, Ryusho Kariya, Sawako Fujikawa, Kenji Maeda, Seiji Okada   +4 more
doaj   +1 more source

Evaluation of Different Parameters of Humoral and Cellular Immune Responses in HIV Serodiscordant Heterosexual Couples: Humoral Response Potentially Implicated in Modulating Transmission Rates

EBioMedicine, 2017
As the HIV/AIDS pandemic still progresses, understanding the mechanisms governing viral transmission as well as protection from HIV acquisition is fundamental.
María Julia Ruiz, Jimena Salido, Lorena Abusamra, Yanina Ghiglione, Cintia Cevallos, Gabriel Damilano, Ana María Rodriguez, César Trifone, Natalia Laufer, Luis D. Giavedoni, Omar Sued, Horacio Salomón, María Magdalena Gherardi, Gabriela Turk   +13 more
doaj   +1 more source

High levels of anti‐Nef antibodies may prevent AIDS disease progression in vertically HIV‐1‐infected infants

Journal of the International AIDS Society, 2014
Introduction HIV‐1‐associated CD4+ T‐cell depletion is a consequence of uninfected cell death. Nef is one of the viral factors that trigger apoptosis on bystander cells, though the plasma Nef levels do not correlate with Th lymphocytes counts. The aim of
Guillermo Corró, Cintia Milena Crudeli, Carlos Alberto Rocco, Silvia Alejandra Marino, Luisa Sen   +4 more
doaj   +1 more source

PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival

Viruses, 2015
Human T-cell leukemia virus type-1 (HTLV-1) is a tumorigenic retrovirus responsible for development of adult T-cell leukemia/lymphoma (ATLL). This disease manifests after a long clinical latency period of up to 2–3 decades.
Amanda R. Panfil, Jacob Al-Saleem, Cory M. Howard, Jessica M. Mates, Jesse J. Kwiek, Robert A. Baiocchi, Patrick L. Green   +6 more
doaj   +1 more source

ES cell potency fluctuates with endogenous retrovirus activity

Nature, 2012
Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all extraembryonic tissues.
T. Macfarlan, Wesley D. Gifford, Shawn P. Driscoll, Karen Lettieri, Helen M. Rowe, D. Bonanomi, A. Firth, O. Singer, D. Trono, S. Pfaff   +9 more
semanticscholar   +1 more source

GITR triggering has limited impact on HIV-specific CD8 T-cell function but enhances HIV transcription reactivation from latently infected CD4 T-cells

Scientific Reports
Glucocorticoid-Induced TNFR-related protein (GITR) is a costimulatory molecule involved in the proliferation and effector functions of CD8 + and CD4 + T-cells. Recently, it has gained attention as a novel target for HIV immunotherapy. However, reports on
Alejandro Czernikier, Lucia Baquero, Paula Benencio, Laura A. Osorio Ocampo, Jimena Salido, Ana Gun, María I. Figueroa, Natalia Laufer, Yanina Ghiglione, María F. Pascutti, Gabriela Turk   +10 more
doaj   +1 more source

A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

New England Journal of Medicine, 2014
BACKGROUND In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus–based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully ...
S. Hacein-Bey-Abina, Sy Pai, H. Gaspar, M. Armant, C. Berry, S. Blanche, J., Bleesing, J. Blondeau, H. Boer, K. Buckland, L. Caccavelli, G. Cros, S. D. Oliveira, K. Fernández, D. Guo, C. Harris, G. Hopkins, L. Lehmann, A. Lim, W. B. London, J. C. V. D. Loo, N. Malani, F. Male, P. Malik, M. A. Marinovic, A. Mcnicol, D., Moshous, B. Neven, M. Oleastro, C. Picard, J. Ritz, C. Rivat, A. Schambach, K. L. Shaw, A. E, Sherman, L. E. Silberstein, E. Six, F. Touzot, A. Tsytsykova, J. Xu-Bayford, C. Baum, D. F, Bushman, A. Fischer, D. Kohn, A. Filipovich, L. D. Notarangelo, M. Cavazzana, A. D., Williams, A. Thrasher   +53 more
semanticscholar   +1 more source

Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models

Cells, 2019
Patient-derived xenograft (PDX) models are created by engraftment of patient tumor tissues into immunocompetent mice. Since a PDX model retains the characteristics of the primary patient tumor including gene expression profiles and drug responses, it has
Seiji Okada, Kulthida Vaeteewoottacharn, Ryusho Kariya   +2 more
doaj   +1 more source