Results 31 to 40 of about 117,013 (259)

HTLV-1 intragenic viral enhancer influences immortalization phenotype in vitro, but is dispensable for persistence and disease development in animal models

Frontiers in Immunology, 2022
Human T-cell leukemia virus type 1 (HTLV-1) is the causative infectious agent of adult T-cell leukemia/lymphoma (ATL) and chronic neurological disease.
Victoria Maksimova, Susan Smith, Jaideep Seth, Cameron Phelps, Stefan Niewiesk, Yorifumi Satou, Patrick L. Green, Patrick L. Green, Amanda R. Panfil, Amanda R. Panfil   +9 more
doaj   +1 more source

Death and the retrovirus

Trends in Molecular Medicine, 2003
A flurry of new papers has shown that HIV reverse transcription is vulnerable to G-->A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G.
Vartanian, Jean Pierre, Sommer, Peter, Wain-Hobson, Simon   +2 more
openaire   +2 more sources

Identification and characterization of a novel enhancer in the HTLV-1 proviral genome

Nature Communications, 2022
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al.
Misaki Matsuo, Takaharu Ueno, Kazuaki Monde, Kenji Sugata, Benjy Jek Yang Tan, Akhinur Rahman, Paola Miyazato, Kyosuke Uchiyama, Saiful Islam, Hiroo Katsuya, Shinsuke Nakajima, Masahito Tokunaga, Kisato Nosaka, Hiroyuki Hata, Atae Utsunomiya, Jun-ichi Fujisawa, Yorifumi Satou   +16 more
doaj   +1 more source

Shikonin Induces ROS-Dependent Apoptosis Via Mitochondria Depolarization and ER Stress in Adult T Cell Leukemia/Lymphoma

Antioxidants, 2023
Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in some elderly human T-cell leukemia virus (HTVL-1) carriers.
Piyanard Boonnate, Ryusho Kariya, Seiji Okada   +2 more
doaj   +1 more source

Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?

Viruses, 2015
Background: indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas.
Camila Cánepa, Jimena Salido, Matías Ruggieri, Sindy Fraile, Gabriela Pataccini, Carolina Berini, Mirna Biglione   +6 more
doaj   +1 more source

HIV Env conserved element DNA vaccine alters immunodominance in macaques

Human Vaccines & Immunotherapeutics, 2017
Sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. HIV Env is a highly-glycosylated protein composed of ‘conserved’ and ‘variable’ regions.
Xintao Hu, Antonio Valentin, Margherita Rosati, Siriphan Manocheewa, Candido Alicea, Bhabadeb Chowdhury, Jenifer Bear, Kate E. Broderick, Niranjan Y. Sardesai, Sylvie Le Gall, James I. Mullins, George N. Pavlakis, Barbara K. Felber   +12 more
doaj   +1 more source

Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

Biomolecules, 2023
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL). HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host antiviral immunity; however, 5–10% of carriers lose this balance and develop ATL.
Shingo Nakahata, Daniel Enriquez-Vera, M. Ishrat Jahan, Kenji Sugata, Yorifumi Satou   +4 more
doaj   +1 more source

Cell entry and exit of porcine endogenous retrovirus A: receptors and release inhibitor [PDF]

, 2010
Following the discovery that porcine endogenous retrovirus (PERV) can infect human cells, the potential risk of a zoonotic infection by PERV has been a major obstacle in the xenotransplantation field.
Mattiuzzo, G.
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source