Results 51 to 60 of about 134,326 (264)

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Nature, 2011
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus invasion of the target cell cytoplasm.
Thomas Pertel, S. Hausmann, Damien Morger, Sara Züger, J. Guerra, Josefina Lascano, Christian Reinhard, F. Santoni, P. Uchil, L. Chatel, A. Bisiaux, M. Albert, Caterina Strambio‐De‐Castillia, W. Mothes, M. Pizzato, M. Grütter, J. Luban   +16 more
semanticscholar   +1 more source

Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4

International Immunology, 2015
The envelope protein of an MS-associated retrovirus activates brain ...
A. Duperray, Delphin Barbe, G. Raguénez, B. Weksler, I. Romero, P. Couraud, H. Perron, P. Marche   +7 more
semanticscholar   +1 more source

Morphology and ultrastructure of retrovirus particles

AIMS Biophysics, 2015
Retrovirus morphogenesis entails assembly of Gag proteins and the viral genome on the host plasma membrane, acquisition of the viral membrane and envelope proteins through budding, and formation of the core through the maturation process.
Wei Zhang, Sheng Cao, Jessica L. Martin, Joachim D. Mueller, L. Mansky   +4 more
semanticscholar   +1 more source

HIV-Tocky system to visualize proviral expression dynamics

Communications Biology
Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir comprises a rare fraction of infected cells that can survive host and virus-mediated killing.
Omnia Reda, Kazuaki Monde, Kenji Sugata, Akhinur Rahman, Wajihah Sakhor, Samiul Alam Rajib, Sharmin Nahar Sithi, Benjy Jek Yang Tan, Koki Niimura, Chihiro Motozono, Kenji Maeda, Masahiro Ono, Hiroaki Takeuchi, Yorifumi Satou   +13 more
doaj   +1 more source

Synergistic effects of HDAC inhibitor tucidinostat and ENT inhibitor dipyridamole in T-cell malignancies

Scientific Reports
Achieving both selectivity and cytotoxicity against cancer cells remains a major challenge in cancer therapy. Histone deacetylase (HDAC) inhibitors, such as tucidinostat, suppress tumor growth by epigenetically regulating tumor suppressor gene expression
Jiazhou Li, Ahmed E. Goda, Daniel Enriquez-Vera, Shuhei Fujii, Satomi Harazono, Jhajaira M. Araujo, Nao Nishikoba, Sophia Velarde, Atakan Zeki Namli, Alvaro De Jesus Huamani Ortiz, Shingo Nakahata   +10 more
doaj   +1 more source

Imaging Flow Cytometry in HIV Infection Research: Advantages and Opportunities

Methods and Protocols
The human immunodeficiency virus (HIV) is a type of retrovirus that infects humans and belongs to the Lentivirus group. Despite the availability of effective treatments, HIV infections are still increasing in some parts of the world, according to the ...
Kirill. A. Elfimov, Dmitriy. A. Baboshko, Natalya. M. Gashnikova   +2 more
doaj   +1 more source

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP

Retrovirology, 2019
Background Human T cell leukaemia virus type 1 (HTLV-1) is a retrovirus associated with human diseases such as adult T-cell leukaemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis.
Paola Miyazato, Misaki Matsuo, Benjy J. Y. Tan, Michiyo Tokunaga, Hiroo Katsuya, Saiful Islam, Jumpei Ito, Yasuhiro Murakawa, Yorifumi Satou   +8 more
doaj   +1 more source

Emerging Role of LY6E in Virus–Host Interactions

Viruses, 2019
As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis.
Jingyou Yu, Shan-Lu Liu
doaj   +1 more source

The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage

Viruses, 2018
Interferon inducible transmembrane proteins (IFITMs) are one of several IFN-stimulated genes (ISGs) that restrict entry of enveloped viruses, including flaviviruses, filoviruses and retroviruses.
Jingyou Yu, Shan-Lu Liu
doaj   +1 more source

YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity

Journal of Virology
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neurodegenerative disease.
Emily M. King, Amanda Midkiff, Karsyn McClain, Sanggu Kim, Amanda R. Panfil   +4 more
doaj   +1 more source