Results 81 to 90 of about 1,390,032 (400)
Replication fork reversal triggers fork degradation in BRCA2-defective cells
Nature Communications, 2017 Besides its role in homologous recombination, the tumor suppressor BRCA2 protects stalled replication forks from nucleolytic degradation. Defective fork stability contributes to chemotherapeutic sensitivity of BRCA2-defective tumors by yet-elusive ...
S. Mijic +10 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Lipolysis sensation by white fat afferent nerves triggers brown fat thermogenesis
Molecular Metabolism, 2016 Objective: Metabolic challenges, such as a cold environment, stimulate sympathetic neural efferent activity to white adipose tissue (WAT) to drive lipolysis, thereby increasing the availability of free fatty acids as one source of fuel for brown adipose ...
John T. Garretson +5 more
doaj
Frontiers in Medicine, 2022 BackgroundLittle is known about the recent use of neuromuscular blocking agents (NMBAs) and monitoring in China. This paper presents the results of a nationwide survey conducted to obtain information regarding the current management of NMBAs in China ...
HaoTian Wu +7 more
doaj +1 more source
The $\aleph$-Calculus: A declarative model of reversible programming [PDF]
arXiv, 2022 A novel model of reversible computing, the $\aleph$-calculus, is introduced. It is declarative, reversible-Turing complete, and has a local term-rewriting semantics. Unlike previously demonstrated reversible term-rewriting systems, it does not require the accumulation of history data.
arxiv
Spontaneous symmetry breaking in a spin-orbit coupled $f=2$ spinor condensate
, 2015 We study the ground-state density profile of a spin-orbit coupled $f=2$ spinor condensate in a quasi-one-dimensional trap. The Hamiltonian of the system is invariant under time reversal but not under parity.
Adhikari, S. K., Gautam, Sandeep
core +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Impact of Sugammadex Versus Neostigmine/Glycopyrrolate on Perioperative Efficiency
ClinicoEconomics and Outcomes Research, 2020 Niaz Deyhim,1,2 Amanda Beck,1 Jonathan Balk,1 Michael G Liebl3 1Department of Pharmacy Services, Houston Methodist Hospital, Houston, TX, USA; 2Department of Pharmacy Practice, University of Houston College of Pharmacy, Houston, TX, USA; 3Department of ...
Deyhim N, Beck A, Balk J, Liebl MG
doaj
Thoracic Cancer, 2021 Background Chemoresistance is a major barrier limiting the therapeutic efficacy of late stage non‐small cell lung cancer (NSCLC). In this study, we sought to use two‐dimensional titanium carbide (2D Ti2C) to reverse cisplatin resistance in NSCLC. Methods
Yue Zhu, Baiyan Sui, Xin Liu, Jiao Sun
doaj +1 more source