Results 91 to 100 of about 50,432 (316)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Novel 4H-SiC Double-Trench MOSFETs with Integrated Schottky Barrier and MOS-Channel Diodes for Enhanced Breakdown Voltage and Switching Characteristics

Nanomaterials
In this study, a novel silicon carbide (SiC) double-trench MOSFET (DT-MOS) combined Schottky barrier diode (SBD) and MOS-channel diode (MCD) is proposed and investigated using TCAD simulations. The integrated MCD helps inactivate the parasitic body diode
Peiran Wang, Chenglong Li, Chenkai Deng, Qinhan Yang, Shoucheng Xu, Xinyi Tang, Ziyang Wang, Wenchuan Tao, Nick Tao, Qing Wang, Hongyu Yu   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reliability Assessment of 650-V Schottky p-GaN HEMTs Under Reverse Conduction Stress [PDF]

The GaN-based high-electron mobility transistors (HEMTs) can operate efficiently in reverse conduction mode without requiring an intrinsic antiparallel diode, reducing power losses and enabling higher switching frequencies.
Tallarico A. N., Smerzi S. A., Iucolano F., Bevilacqua S., Fiegna C., Cioni M., Millesimo M., Russo A.   +7 more
core   +1 more source

Bond valence analysis of reverse Monte Carlo produces structural models; A way to understand ion conduction in glasses [PDF]

, 2005
Reverse Monte Carlo (RMC) modelling is now widely used for obtaining structural models of amorphous materials that are in quantitative agreement with available experimental structure data.
Adams, S., Swenson, Jan, Swenson, J.
core   +1 more source

Design and TCAD Simulation of GaN P-i-N Diode with Multi-Drift-Layer and Field-Plate Termination Structures

Micromachines
Vertical GaN P-i-N diodes exhibit excellent high-voltage performance, fast switching speed, and low conduction losses, making them highly attractive for power applications.
Zhibo Yang, Guanyu Wang, Yifei Wang, Pandi Mao, Bo Ye   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Error analysis of forward and reverse heat conduction and convection calculations considering uncertainties in welding [PDF]

, 2009
Numerical models of fusion welding traditionally compute temperature field for a given set of welding conditions in a forward manner. The reliability of computed temperature profile depends on the accuracy of a number of model input parameters, values of
DE, A, BAG, S
core   +1 more source

Support Vector Machine for Prediction of the Electronic Factors of a Schottky Configuration Interlaid with Pure PVC and Doped by Sm2O3 Nanoparticles

Advanced Electronic Materials
This work uses the Support Vector Machine (SVM) to predict the main electronic variables of metal‐semiconductor (MS) and metal‐nanocomposite‐semiconductor (MPS) configurations, i.e., leak current (I0), the height of the potential barrier (ΦB0), ideality ...
Yashar Azizian‐Kalandaragh, Ali Barkhordari, Yosef Badali   +2 more
doaj   +1 more source