Results 61 to 70 of about 50,432 (316)

Gate driver IC for enhancement mode GaN power transistors with senseFET reverse conduction detection circuit

IET Power Electronics, 2019
Dead-times are necessary in switching output stage to avoid shoot-through current between the high side (HS) and the low side (LS) power transistors. However, excessively long dead-times can lead to unwanted reverse conduction and power loss. Sensing the
Wei Jia Zhang, Yahui Leng, Jingshu Yu, Xiaoxue Jiang, ChuYao Cheng, W. Ng   +5 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Heart rate reduction after ivabradine might be associated with reverse electrical remodeling in patients with cardiomyopathy and left bundle branch block

Journal of International Medical Research, 2018
Left bundle branch block increases the risk of death in patients with chronic heart failure. We herein report four clinical cases of patients with chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block that occurred when
Andrea Kučerová, Petr Doškář, Libor Dujka, Veronika Lekešová, Petr Volf, Katarina Koščová, Petr Neužil, Filip Málek   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Prospects and Challenges of 4H-SiC Thyristors in Protection of HB-MMC-VSC-HVDC Converters

IEEE Open Journal of Power Electronics, 2021
Pole-to-pole DC faults on HB-MMC-VSC-HVDC schemes impose significant risk of cascade failure on IGBT/diode pairs. Other novel topologies with fault blocking capability, i.e. AAC converters, and DC circuit breakers are not yet fully matured.
Chengjun Shen, Saeed Jahdi, Olayiwola Alatise, Jose Ortiz-Gonzalez, Avinash Aithal, Phil Mellor   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Integrated Gate Driver for E-mode GaN HEMTs with Active Clamping for Reverse Conduction Detection [PDF]

, 2019
Detection of reverse-conduction in GaN-based switched-mode power converters is essential to reduce power loss and to protect the circuit from severe undershoot voltage.
Wei Jia Zhang, Zhang, Wei Jia, Yahui Leng, Yu Shen Lu, Ng, Wai Tung, Chu Yao Cheng, Cheng, Chu Yao, Yu, Jingshu, Wai Tung Ng, Leng, Yahui, Jingshu Yu, Lu, Yu Shen   +11 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Linear Equivalent Model for VHF Class Φ₂ Inverter Based on Spectrum Quantification Method to Reduce GaN Reverse Conduction Loss

IEEE Access, 2021
Reverse conduction loss of GaN high electron mobility transistors (HEMTs) in very high frequency (VHF) converters is non-neglectable due to the absence of body diode.
Desheng Zhang, Dian Lyu, Ming Zhang, Mengxue Dong, Run Min, Qiao Zhang, Qiaoling Tong, Xuecheng Zou   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source