Results 141 to 150 of about 318,711 (246)

Reverse Engineering Caged Compounds: Design Principles for their Application in Biology. [PDF]

Angew Chem Int Ed Engl, 2023
Ellis-Davies GCR.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Author Correction: Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes. [PDF]

Nat Plants
Zhang S, Liu S, Lai HF, Bender KW, Kim G, Caflisch A, Zipfel C.   +6 more
europepmc   +1 more source

Stimulation-mediated reverse engineering of silent neural networks.

J Neurophysiol, 2023
Ren X, Bok I, Vareberg A, Hai A.
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Reverse engineering neuron-type-specific and type-orthogonal splicing-regulatory networks using diverse cellular transcriptomes. [PDF]

Cell Rep
Moakley DF, Campbell M, Anglada-Girotto M, Feng H, Califano A, Au E, Zhang C.   +6 more
europepmc   +1 more source

Reverse engineering environmental metatranscriptomes clarifies best practices for eukaryotic assembly. [PDF]

BMC Bioinformatics, 2023
Krinos AI, Cohen NR, Follows MJ, Alexander H.   +3 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Adaptive evolution and reverse engineering to explore the low pH tolerance mechanisms of <i>Streptomyces albulus</i>. [PDF]

Appl Environ Microbiol
Liu Y, Liu T, Zhang Y, Wang L, Zhang H, Zhang J, Chen X.   +6 more
europepmc   +1 more source

Effect of Reverse Engineering Pedagogy on Primary School Students' Computational Thinking Skills in STEM Learning Activities. [PDF]

J Intell, 2023
Liu X, Wang X, Xu K, Hu X.
europepmc   +1 more source