Results 141 to 150 of about 4,446,471 (346)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Reverse Engineering and Cognition Panglossian Memories?

open access: yesIdeas y Valores, 2014
Daniel C. Dennett has dedicated a great part of his work to the conception of an application of reverse engineering and adaptationism in order to explain the evolution of the human mind.
Liliana Chaves Castaño   +1 more
doaj  

A Survey on Application of AI on Reverse Engineering for Software Analysis and Security

open access: yesIEEE Access
Reverse engineering process serves essential functions in software analysis and security auditing and malware detection but requires significant time and effort.
Ashutosh Ghimire   +4 more
doaj   +1 more source

The Effectiveness Of Bytecode Decompilation [PDF]

open access: yes
High-level bytecodes used by object-oriented managed execution environments make it easy to decompile them. This paper studies the reasons that make bytecode decompilers such efficient and presents basic obfuscation techniques as an efficient protection ...
Robert Enyedi
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Reverse Engineering Socialbot Infiltration Strategies in Twitter [PDF]

open access: yes, 2014
Data extracted from social networks like Twitter are increasingly being used to build applications and services that mine and summarize public reactions to events, such as traffic monitoring platforms, identification of epidemic outbreaks, and public ...
Adriano Veloso   +4 more
core   +1 more source

Adaptive laboratory evolution and reverse engineering enhances autotrophic growth in Pichia pastoris.

open access: yesMetabolic Engineering, 2021
T. Gassler   +4 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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