Results 1 to 10 of about 1,758,180 (373)

A reverse transcriptase ribozyme

eLife, 2017
A highly evolved RNA polymerase ribozyme was found to also be capable of functioning as a reverse transcriptase, an activity that has never been demonstrated before for RNA. This activity is thought to have been crucial for the transition from RNA to DNA
Biswajit Samanta, Gerald F Joyce
doaj   +4 more sources

The Discovery of Reverse Transcriptase.

Annual Review of Virology, 2016
In 1970 the independent and simultaneous discovery of reverse transcriptase in retroviruses (then RNA tumor viruses) by David Baltimore and Howard Temin revolutionized molecular biology and laid the foundations for retrovirology and cancer biology. In this historical review we describe the formulation of the controversial provirus hypothesis by Temin,
J. Coffin, Hung Fan
semanticscholar   +3 more sources

Comparison of Reverse Transcriptase Loop-Mediated Isothermal Amplification and Reverse Transcriptase Polymerase Chain Reaction for Detection of Prostate Specific Antigen

Basic & Clinical Cancer Research, 2019
Background: Research shows that prostate cancer ranks second among the top five most common cancers in men. It has been confirmed that if the circulating Prostate Specific Antigen (PSA) transcripts are detected successfully, the prostate cancer cells ...
Mohammad Amin Almasi, Marya Esmaili
doaj   +2 more sources

Reverse Transcriptase [PDF]

Definitions, 2020
B. Samanta, G. F. Joyce
semanticscholar   +3 more sources

Molecular mechanism of the type 2 defense-associated reverse transcriptase. [PDF]

Nucleic Acids Res
Liu Z, Liao F, Wu W, Zhang C, Yue C, Chen A, Zhang S, Liu Y, Liu B, Han J, Zhang C, Wang X, Li X, Li Z, Zhang H, Yin H.   +15 more
europepmc   +2 more sources

Avoiding Drug Resistance in HIV Reverse Transcriptase.

Chemical Reviews, 2021
HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of HIV and has been a key target of anti-HIV drug development efforts.
Maria E. Cilento, K. Kirby, S. Sarafianos   +2 more
semanticscholar   +1 more source

Retroviral restriction factor APOBEC3G delays the initiation of DNA synthesis by HIV-1 reverse transcriptase. [PDF]

PLoS ONE, 2013
It is well established that the cytosine deaminase APOBEC3G can restrict HIV-1 virions in the absence of the virion infectivity factor (Vif) by inducing genome mutagenesis through deamination of cytosine to uracil in single-stranded HIV-1 (-)DNA. However,
Madison B Adolph, Jonathon Webb, Linda Chelico   +2 more
doaj   +1 more source

Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage [PDF]

PeerJ, 2022
Background Angiogenesis is an endogenous repair mechanism following hypoxic-ischemic brain damage (HIBD). Interestingly, recent studies have shown that angiogenesis can be regulated by telomerase reverse transcriptase (TERT), a critical component of ...
Jiao Li, Yi Feng, Jing Zhao, Zhi Fang, Haiting Liu   +4 more
doaj   +2 more sources

Reverse transcriptase inhibition: a way to defeat HIV

HIV & AIDS Review. International Journal of HIV-Related Problems, 2022
Human immunodeficiency virus (HIV) induces disease in humans that is known as AIDS (acquired immunodeficiency syndrome). First AIDS cases were registered in 1981, and later, types of HIV infection, such as HIV-1 and HIV-2 were identified.
Vikas Kumar, Harish Joshi, I. Pandey
doaj   +1 more source

Cost-effectiveness of the third-agent class in treatment-naive human immunodeficiency virus-infected patients in Portugal. [PDF]

PLoS ONE, 2012
IntroductionCurrent Portuguese HIV treatment guidelines recommend initiating antiretroviral therapy with a regimen composed of two Nucleoside Reverse Transcriptase Inhibitors plus one Non-nucleoside Reverse Transcriptase Inhibitor (2NRTI+NNRTI) or two ...
Filipa Aragão, José Vera, Inês Vaz Pinto   +2 more
doaj   +1 more source