Results 41 to 50 of about 1,799,385 (351)

The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.

Journal of Medicinal Chemistry, 2018
Human immunodeficiency virus (HIV) infection is now pandemic. Targeting HIV-1 reverse transcriptase (HIV-1 RT) has been considered as one of the most successful targets for the development of anti-HIV treatment.
V. Namasivayam, Murugesan Vanangamudi, Victor G. Kramer, Sonali Kurup, P. Zhan, Xinyong Liu, J. Kongsted, S. Byrareddy   +7 more
semanticscholar   +1 more source

Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation

mBio, 2023
Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or “retrotransposons,” mobilize through the production of an RNA intermediate that is then reverse transcribed to form complementary DNA
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Morgan M. O’Mara, Jez L. Marston, Tongyi Fei, Matthew L. Bendall, Douglas F. Nixon   +7 more
doaj   +1 more source

Base modifications affecting RNA polymerase and reverse transcriptase fidelity

Nucleic Acids Research, 2018
Ribonucleic acid (RNA) is capable of hosting a variety of chemically diverse modifications, in both naturally-occurring post-transcriptional modifications and artificial chemical modifications used to expand the functionality of RNA. However, few studies
V. Potapov, Xiaoqing Fu, Nan Dai, Ivan R. Corrêa, N. Tanner, J. L. Ong   +5 more
semanticscholar   +1 more source

Stabilized reverse transcriptase fusion proteins [PDF]

, 2016
Stabilized reverse transcriptase fusion proteins including a thermostable reverse transcriptase connected to a stabilizer protein are described. Attaching the stabilizer protein to the thermostable reverse transcriptase stabilizes the fusion protein and ...
Lambowitz, Alan M., Mohr, Sabine, Mohr, Georg, Ghanem, Eman   +3 more
core   +1 more source

Relevance of micrometastases detected by reverse transcriptase-polymerase chain reaction for melanoma recurrence: systematic review and meta-analysis

São Paulo Medical Journal
CONTEXT: Cutaneous melanoma presents significant morbidity and mortality. Nowadays, about 90% of them are diagnosed by clinical examination and most are localized melanomas.
Allisson Monteiro da Silva, Renato Santos de Oliveira Filho, Lydia Masako Ferreira, Humberto Saconato   +3 more
doaj   +1 more source

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

Journal of Biomedical Sciences, 2018
BackgroundLimitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation.
R. Leão, J. Apolónio, Donghyun D Lee, A. Figueiredo, U. Tabori, P. Castelo-Branco   +5 more
semanticscholar   +1 more source

Impact of the N348I Mutation in HIV-1 Reverse Transcriptase on Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Non-Subtype B HIV-1

, 2011
We investigated the effect of N348I alone and with M184V on nonnucleoside reverse transcriptase inhibitor (NNRTI) drug susceptibility and replicative capacity in B and non-B HIV-1 isolates.
Michael Chirara, Cissy Kityo, Kaleebu, P., Pontiano Kaleebu, Pillay, D., Greg J. Towers, Crombe, A., Towers, G.J., Kityo, C., Adele L. McCormick, Chirara, M., Ravindra K. Gupta, Gupta, R.K., Goodall, R.L., Chris M. Parry, Anne Crombe, Ruth L. Goodall, Deenan Pillay, Parry, C.M., McCormick, A.L.   +19 more
core   +1 more source

Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection [PDF]

, 2004
The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration less than or equal to0.4-fold that of HIV type 1(NL4-3) (HIV-1(NL4-3)) to ritonavir ...
Joseph B. Margolick, Routy, JP, Susan J. Little, Frost, SDW, Leigh Brown, AJ, Connick, E, Little, SJ, Markowitz, M, Elizabeth Connick, Douglas D. Richman, Collier, AC, Richman, DD, Hellmann, NS, Brian Conway, Daar, ES, Good, B, Jacques Corbeil, Eric S. Daar, Margolick, JB, Simon D. W. Frost, Corbeil, J, Jean-Pierre Routy, Nicholas S. Hellmann, Benjamin Good, Viviana Simon, Simon, V, Ann C. Collier, Martin Markowitz, Conway, B, Andrew J. Leigh Brown   +29 more
core   +1 more source

Small Dumbbell Oligonucleotides Inhibitors of RNase H Activity of MOMULV Reverse Transcriptase

E-Journal of Chemistry, 2011
The small dumbbell oligonucleotides containing loops of phosphodiester (OL-1), two trimethylene, C3 moieties in each loop (OL-2) and phosphorothioate (OL-3) linkages were synthesized.
Ajay Kumar
doaj   +1 more source

The Molecular Docking of Specific Reverse Transcriptase Inhibitory Ligands onto the Molecular Model of HIV-1 Reverse Transcriptase [PDF]

Trends in Pharmaceutical Sciences
HIV-1 reverse transcriptase (RT) is a crucial enzyme in HIV replication and AIDS progression. It consists of p66 and p51 subunits and converts viral RNA into double-stranded DNA for integration into the host cell's genome.
Roohallah Yousefi
doaj   +1 more source