Results 21 to 30 of about 965,759 (306)

COVID-19 Diagnosed by Real-Time Reverse Transcriptase-Polymerase Chain Reaction in Nasopharyngeal Specimens of Suspected Cases in a Tertiary Care Center: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association, 2021
Introduction: The emergence of severe acute respiratory syndrome coronavirus-2 pandemic is critically challenging the whole world. The real-time reverse transcriptase-polymerase chain reaction is the most widely used confirmatory test for COVID-19 ...
Narayani Maharjan, Niresh Thapa, Bibek Pun Magar, Muna Maharjan, Jiancheng Tu   +4 more
doaj   +1 more source

High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs

Nature Communications, 2021
Initiation of HIV-1 reverse transcription occurs at the host tRNALys 3, which forms a complex with the 5’ end of the HIV-1 viral RNA and reverse transcriptase (RT).
Betty Ha, Kevin P. Larsen, Jingji Zhang, Ziao Fu, Elizabeth Montabana, Lynnette N. Jackson, Dong-Hua Chen, Elisabetta Viani Puglisi   +7 more
doaj   +1 more source

There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer [PDF]

, 2004
Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel, Newbold, RF, Katharine L Kirkpatrick, Kirkpatrick, KL, Mokbel, K, Robert F Newbold   +5 more
core   +1 more source

Telomeres in Evolution and Development from Biosemiotic Perspective [PDF]

, 2007
Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
core   +1 more source

Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation

mBio, 2023
Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or “retrotransposons,” mobilize through the production of an RNA intermediate that is then reverse transcribed to form complementary DNA
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Morgan M. O’Mara, Jez L. Marston, Tongyi Fei, Matthew L. Bendall, Douglas F. Nixon   +7 more
doaj   +1 more source

Oligonucleotide primers for quantitative real-time reverse-transcriptase-polymerase chain reaction.

, 2018
Oligonucleotide primers for quantitative real-time reverse-transcriptase-polymerase chain reaction.
Craig A. Goodman (162962), Mary Behan (308210), Zhengling Hao (308207), Susannah J. Sample (308203), Troy A. Hornberger (126826), Ermias Amene (3092493), Jason A. Bleedorn (342553), Mark D. Markel (297920), Peter Muir (308211)   +8 more
core   +1 more source

Stabilized reverse transcriptase fusion proteins [PDF]

, 2010
Stabilized reverse transcriptase fusion proteins including a thermostable reverse transcriptase connected to a stabilizer protein are described. Attaching the stabilizer protein to the thermostable reverse transcriptase stabilizes the fusion protein and ...
Lambowitz, Alan M., Mohr, Sabine, Mohr, Georg, Ghanem, Eman   +3 more
core   +1 more source

Relevance of micrometastases detected by reverse transcriptase-polymerase chain reaction for melanoma recurrence: systematic review and meta-analysis

São Paulo Medical Journal
CONTEXT: Cutaneous melanoma presents significant morbidity and mortality. Nowadays, about 90% of them are diagnosed by clinical examination and most are localized melanomas.
Allisson Monteiro da Silva, Renato Santos de Oliveira Filho, Lydia Masako Ferreira, Humberto Saconato   +3 more
doaj   +1 more source

Impact of the N348I Mutation in HIV-1 Reverse Transcriptase on Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Non-Subtype B HIV-1

, 2011
We investigated the effect of N348I alone and with M184V on nonnucleoside reverse transcriptase inhibitor (NNRTI) drug susceptibility and replicative capacity in B and non-B HIV-1 isolates.
Michael Chirara, Cissy Kityo, Kaleebu, P., Pontiano Kaleebu, Pillay, D., Greg J. Towers, Crombe, A., Towers, G.J., Kityo, C., Adele L. McCormick, Chirara, M., Ravindra K. Gupta, Gupta, R.K., Goodall, R.L., Chris M. Parry, Anne Crombe, Ruth L. Goodall, Deenan Pillay, Parry, C.M., McCormick, A.L.   +19 more
core   +1 more source

Small Dumbbell Oligonucleotides Inhibitors of RNase H Activity of MOMULV Reverse Transcriptase

E-Journal of Chemistry, 2011
The small dumbbell oligonucleotides containing loops of phosphodiester (OL-1), two trimethylene, C3 moieties in each loop (OL-2) and phosphorothioate (OL-3) linkages were synthesized.
Ajay Kumar
doaj   +1 more source