Results 21 to 30 of about 1,799,385 (351)

HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective

Viruses, 2015
HIV-1 Rev is an ~13 kD accessory protein expressed during the early stage of virus replication. After translation, Rev enters the nucleus and binds the Rev response element (RRE), a ~350 nucleotide, highly structured element embedded in the env gene in ...
Jason W. Rausch, Stuart F. J. Le Grice
doaj   +1 more source

APOBEC3 selects V179I in HIV-1 reverse transcriptase to provide selective advantage for non-nucleoside reverse transcriptase inhibitor-resistant mutants

Frontiers in Virology, 2022
The V179I substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is selected in humans or mouse models treated with certain nonnucleoside reverse transcriptase inhibitors (NNRTIs).
Richa Dwivedi, Youya Wang, Christopher Kline, Douglas K. Fischer, Zandrea Ambrose   +4 more
doaj   +1 more source

Efficacy of second-line dolutegravir plus 2 nucleoside reverse transcriptase inhibitors by baseline nucleoside reverse transcriptase inhibitor resistance and nucleoside reverse transcriptase inhibitor use in the DAWNING study

Antiviral Therapy, 2022
Background In the DAWNING study, dolutegravir + 2 nucleoside reverse transcriptase inhibitors (NRTIs) demonstrated superior efficacy at Week 48 and a favourable safety profile compared with lopinavir/ritonavir + 2 NRTIs in adults with HIV-1 failing first-
Dannae Brown, Richard Kaplan, Marcelo Losso, Carlos Brites, Ruolan Wang, Mark Underwood, Judy Hopking, Michael Aboud, Jörg Sievers   +8 more
doaj   +1 more source

Reverse Transcriptase: From Transcriptomics to Genome Editing.

Trends in Biotechnology, 2020
Reverse transcriptases (RTs) are enzymes that can generate a complementary strand of DNA (cDNA) from RNA. Coupled with PCR, RTs have been widely used to detect RNAs and to clone expressed genes.
Samara Martín-Alonso, Estrella Frutos-Beltrán, L. Menéndez-Arias   +2 more
semanticscholar   +1 more source

Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity

Nature Chemistry, 2020
The ability of reverse transcriptases (RTs) to synthesize a complementary DNA from natural RNA and a range of unnatural xeno nucleic acid (XNA) template chemistries, underpins key methods in molecular and synthetic genetics.
G. Houlihan, Sebastian Arangundy-Franklin, B. Porebski, N. Subramanian, Alexander I. Taylor, P. Holliger   +5 more
semanticscholar   +1 more source

In silico prediction of telomerase reverse transcriptase inhibitors using modified retinol for the treatment of arsenical cancer

Bangabandhu Sheikh Mujib Medical University Journal, 2016
Retinol molecule was modified to predict the inhibitors of telomerase reverse transcriptase for the treatment of arsenical cancer through in silico study. Telomerase activity is expressed in the cancerous conditions which can be the target for anticancer
Kipchu Tshering, Mir Misbahuddin
doaj   +1 more source

Reduced susceptibility of human immunodeficiency virus type 1 (HIV-1) from patients with primary HIV infection to nonnucleoside reverse transcriptase inhibitors is associated with variation at novel amino acid sites [PDF]

, 2000
Recently, significant numbers of individuals with primary human immunodeficiency virus (HN) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral drugs.
Jeannette M. Whitcomb, Susan J. Little, Philip H. Keiser, Hellmann, N S, Connick, E, D'Aquila, R T, Elizabeth Connick, Douglas D. Richman, Christos J. Petropoulos, Richard T. D'Aquila, Whitcomb, J M, Joseph K. Wong, Keiser, P H, Brown, A J, Wong, J K, Richman, D D, Heather M. Precious, Eric S. Daar, Huang, W, Wei Huang, Precious, H M, Nicholas S. Hellmann, Marlynne Quigg, Quigg, M, Daar, E S, Little, S J, Andrew J. Leigh Brown, Petropoulos, C J   +27 more
core   +1 more source

Time to treatment disruption in children with HIV-1 randomized to initial antiretroviral therapy with protease inhibitors versus non-nucleoside reverse transcriptase inhibitors.

PLoS ONE, 2020
BackgroundChoice of initial antiretroviral therapy regimen may help children with HIV maintain optimal, continuous therapy. We assessed treatment-naïve children for differences in time to treatment disruption across randomly-assigned protease inhibitor ...
Dwight E Yin, Christina Ludema, Stephen R Cole, Carol E Golin, William C Miller, Meredith G Warshaw, Ross E McKinney, PENPACT-1 (PENTA 9 / PACTG 390) Study Team   +7 more
doaj   +1 more source

Docking Study of HIV-1 Reverse Transcriptase (HIV-1 RT) with Well-Known Nucleoside Reverse Transcriptase Inhibitors (NRTIs) [PDF]

Journal of Advanced Pharmacy Research
Objectives: The nucleic acid-binding cleft in HIV-1 reverse transcriptase (HIV-1 RT) is essential because of its interactions with the polymerase and RNase H active sites. Studying its binding sites for nucleoside reverse transcriptase inhibitors (NRTIs)
Roohallah Yousefi
doaj   +1 more source

Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer

Balkan Medical Journal, 2017
Aims: To investigate the changes in mRNA expression levels of telomerase-related significant proteins in several types of cancer. Methods: Human telomerase reverse transcriptase, pontin, reptin and dyskerin expressions were measured in normal and tumour
Emel Çalışkan Can, M. Can Atalay, Ece Miser Salihoğlu, Ülkü Yalçıntaş Arslan, H. Bolkan Şimşek, Sevgi Yardım Akaydın   +5 more
doaj   +1 more source