Results 51 to 60 of about 1,799,385 (351)
CDK1 dependent phosphorylation of hTERT contributes to cancer progression
Nature Communications, 2020 Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for ...
Mami Yasukawa +18 more
doaj +1 more source
Telomeres in Evolution and Development from Biosemiotic Perspective
, 2007 Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
core +1 more source
Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
Front. Cell Dev. Biol., 2017 Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase ...
Ekta Khattar, V. Tergaonkar
semanticscholar +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Architecture of an HIV-1 reverse transcriptase initiation complex
Nature, 2018 Reverse transcription of the HIV-1 RNA genome into double-stranded DNA is a central step in viral infection1 and a common target of antiretroviral drugs2.
K. Larsen +9 more
semanticscholar +1 more source
There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel +5 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription
Viruses, 2009 There is ample evidence that synthesis of HIV-1 proviral DNA from the viral RNA genome during reverse transcription requires host factors. However, only a few cellular proteins have been described in detail that affect reverse transcription and interact ...
David Harrich +3 more
doaj +1 more source
Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome
New England Journal of Medicine, 2018 ART for the Aicardi–Goutieres Syndrome The genetic encephalopathy Aicardi–Goutieres syndrome is thought to be due to misidentification of self-derived nucleic acids and the induction of a type I in...
G. I. Rice +38 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source