Results 281 to 290 of about 1,799,385 (351)

Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens. [PDF]

mBio
Hullahalli K, Dailey KG, Acbay R, Suzuki M, Balazs GI, Waldor MK.   +5 more
europepmc   +1 more source

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Antiretroviral Activity, Pharmacokinetics, and Safety of MK-8527, an Oral Nucleoside Reverse Transcriptase Translocation Inhibitor, in Adults With HIV-1 Who Had Not Previously Taken Antiretroviral Agents: Results From 2 Open-Label, Phase 1 Studies. [PDF]

Clin Infect Dis
Carstens RP, Kapoor Y, Vargo RC, Bhattacharyya A, Garrett G, Cilissen C, Adedoyin A, Zang X, Denef JF, Leyssens C, Reynders T, Preotescu L, Kaplan R, Rassool M, Lombaard J, Streinu-Cercel A, Matthews RP, Stoch SA, Iwamoto M, Gillespie GL.   +19 more
europepmc   +1 more source

Trade‐offs between surviving and thriving: A careful balance of physiological limitations and reproductive effort under thermal stress

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Balancing survival and reproduction presents a fundamental evolutionary challenge, especially in extreme and unpredictable environments. Thermoregulatory behaviour, in particular, imposes a costly trade‐off, as time spent maintaining optimal body temperature precludes ...
David L. Hubert, Ehren J. Bentz, Robert T. Mason   +2 more
wiley   +1 more source

Effectiveness of Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide from Rilpivirine or Other Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)-Based Antiretroviral Therapy in Virologically Suppressed People with HIV: A Retrospective Analysis (DRIVE-SWITCH Study). [PDF]

Infect Dis Ther
Gagliardini R, Caioli A, Fusto M, Ottou S, Forbici F, Fabeni L, Maggi F, Plazzi MM, De Zottis F, Bellagamba R, Paulicelli J, Mastrorosa I, Grilli E, Pinnetti C, Mazzotta V, Caldera R, Forcina G, Antinori A.   +17 more
europepmc   +1 more source

A novel variant of telomerase reverse transcriptase (TERT) associated with risk of glioma in a Korean population. [PDF]

Sci Rep
Lim HY, Cheong HS, Namgoong S, Chang JH, Kim LH, Shin HD.   +5 more
europepmc   +1 more source

Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles. [PDF]

Sci Adv
Wang Z, Rumrill S, Kang D, Guma SD, Feng D, De Clercq E, Pannecouque C, Chen CH, Arnold E, Ruiz FX, Liu X, Zhan P.   +11 more
europepmc   +1 more source

Association between Nucleoside and Nucleotide Reverse Transcriptase Inhibitor Use and Primary Open-Angle Glaucoma Risk in All of Us. [PDF]

Ophthalmology
Pham K, Jin F, Lee R, Di Rosa I, Salowe R, Ying GS, O'Brien JM.   +6 more
europepmc   +1 more source

De novo gene synthesis by an antiviral reverse transcriptase. [PDF]

Science
Tang S, Conte V, Zhang DJ, Žedaveinytė R, Lampe GD, Wiegand T, Tang LC, Wang M, Walker MWG, George JT, Berchowitz LE, Jovanovic M, Sternberg SH.   +12 more
europepmc   +1 more source

Correction to "SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression". [PDF]

Mol Oncol
europepmc   +1 more source