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Recent discoveries in HIV-1 reverse transcriptase inhibitors.
Current opinion in pharmacology (Print), 2020HIV-1 reverse transcriptase inhibitors (RTIs) are indispensable components of highly active antiretroviral therapy (HAART), which has achieved great success in controlling AIDS epidemic in reducing drastically the morbidity and mortality of HIV-infected ...
Shuang‐Xi Gu +6 more
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Current opinion in pharmacology (Print), 2020
The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of HIV-1 reverse transcriptase and are classified into generations depending on their discovery and resistance profiles.
Murugesan Vanangamudi +2 more
semanticscholar +1 more source
The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of HIV-1 reverse transcriptase and are classified into generations depending on their discovery and resistance profiles.
Murugesan Vanangamudi +2 more
semanticscholar +1 more source
Biochemical and Biophysical Research Communications, 1974
Summary Purified DNA polymerase (“reverse transcriptase”) from avian myeloblastosis virus was analyzed for zinc by atomic absorption spectroscopy. Tightly bound zinc was present in a stoichiometry approximating 1 gm atom/mole of enzyme. Inhibition by the chelating agent, ortho -phenanthroline, and lack of inhibition by its non-chelating analog ...
B J, Poiesz, N, Battula, L A, Loeb
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Summary Purified DNA polymerase (“reverse transcriptase”) from avian myeloblastosis virus was analyzed for zinc by atomic absorption spectroscopy. Tightly bound zinc was present in a stoichiometry approximating 1 gm atom/mole of enzyme. Inhibition by the chelating agent, ortho -phenanthroline, and lack of inhibition by its non-chelating analog ...
B J, Poiesz, N, Battula, L A, Loeb
openaire +2 more sources
Reverse transcriptase in bacteria
Molecular Microbiology, 1989SummaryReverse transcriptase, discovered in 1970 in retroviruses, has until recently been found only in eukaryotic organisms. Recently it was shown to occur in two groups of bacteria: myxobacteria and Escherichia coli. The gene for reverse transcriptase is part of a chromosomal genetic element that codes for the production of a branched DNA‐RNA ...
D, Lim, W K, Maas
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Retroviral reverse transcriptases
Cellular and Molecular Life Sciences, 2010Reverse transcription is a critical step in the life cycle of all retroviruses and related retrotransposons. This complex process is performed exclusively by the retroviral reverse transcriptase (RT) enzyme that converts the viral single-stranded RNA into integration-competent double-stranded DNA.
Alon, Herschhorn, Amnon, Hizi
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Bacterial reverse transcriptase and msDNA
Virus Genes, 1995Retrons are a new class of genetic elements found in the chromosome of a large number of different bacteria. These elements code for a reverse transcriptase (RT) that is structurally similar to the polymerases of retroviruses. The retron associated RT is responsible for the production of an unusual extrachromosomal satellite DNA, known as multicopy ...
S A, Rice, B C, Lampson
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Biochemical Education, 1995
Abstract The reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1) converts the single-stranded (+) viral RNA genome into double¬ stranded proviral DNA prior to its integration into the host genomic DNA. The HIV-1 RT has therefore been the target for anti-viral drug design (1). The cloning of the RT in biologically
W A Beard, S H Wilson
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Abstract The reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1) converts the single-stranded (+) viral RNA genome into double¬ stranded proviral DNA prior to its integration into the host genomic DNA. The HIV-1 RT has therefore been the target for anti-viral drug design (1). The cloning of the RT in biologically
W A Beard, S H Wilson
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A split prime editor with untethered reverse transcriptase and circular RNA template
Nature Biotechnology, 2022Bin Liu +8 more
semanticscholar +1 more source
tRNAs as primer of reverse transcriptases
Biochimie, 1995Genetic elements coding for proteins that present amino acid identity with the conserved motifs of retroviral reverse transcriptases constitute the retroid family. With the exception of reverse transcriptases encoded by mitochondrial plasmids of Neurospora, all reverse transcriptases have an absolute requirement for a primer to initiate DNA synthesis ...
R, Marquet +3 more
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