Results 291 to 300 of about 570,932 (356)

Clinical impact of real‐time androgen receptor alteration monitoring on metastatic castration‐resistant prostate cancer treatment in real‐world settings

International Journal of Cancer, EarlyView.
What's New? Androgen receptor (AR) alterations contribute to treatment resistance against androgen receptor signaling inhibitors in metastatic castration‐resistant prostate cancer. This real‐world study demonstrates that AR monitoring via liquid biopsy predicts treatment response and progression in metastatic castration‐resistant prostate cancer.
Regina Stitz, Franz Stoiber, Renè Silye, Elisabeth Rebhan, Michael Dunzinger, Franz Pühringer, Ellen Heitzer, Cornelia Hauser‐Kronberger   +7 more
wiley   +1 more source

Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus. [PDF]

Vet World
Longa-Bobadilla V, Ormeño-Vásquez P, Criollo-Orozco M, Tataje-Lavanda L, Huamán-Gutierrez K, Montalván Á, Zimic M, Fernández-Sanchez M, Fernández-Díaz M.   +8 more
europepmc   +1 more source

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, EarlyView.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

Thymidine Analogue Mutations with M184V Significantly Decrease Phenotypic Susceptibility of HIV-1 Subtype C Reverse Transcriptase to Islatravir. [PDF]

Viruses
Byun H, Papathanasopoulos MA, Steegen K, Basson AE.   +3 more
europepmc   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source

No accelerated progression of subclinical atherosclerosis with integrase strand transfer inhibitors compared to non-nucleoside reverse transcriptase inhibitors. [PDF]

J Antimicrob Chemother
García-Abellán J, García JA, Padilla S, Fernández-González M, Agulló V, Mascarell P, Botella Á, Gutiérrez F, Masiá M.   +8 more
europepmc   +1 more source

Recent advances in isothermal amplification techniques coupled with clustered regularly interspaced short palindromic repeat/Cas systems

Interdisciplinary Medicine, EarlyView.
Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu, Yajun Hou, Yuhang Cheng, Ziyun Li, Jiawei Zeng, Li Li, Jinyong Luo, Bo Shen   +7 more
wiley   +1 more source

Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases. [PDF]

Molecules
Tu NQ, Richetta C, Putzu F, Delelis O, Ahmed K, Masand VH, Schobert R, Tramontano E, Corona A, Biersack B.   +9 more
europepmc   +1 more source

Advanced single‐cell RNA sequencing in tumor immunology

Interdisciplinary Medicine, EarlyView.
This review highlights the applications of advanced single‐cell RNA sequencing (scRNA‐seq) technologies in tumor immunology. It summarizes representative scRNA‐seq methods according to technical principles, with a focus on single‐cell T cell receptor sequencing. This review also discusses how scRNA‐seq is used to construct immune cell atlases of tumors,
Yilong Liu, Xiyuan Yu, Zhipeng Han, Qiuyang Wei, Qi Niu, Chaoyong Yang, Jie P. Li, Zijian Guo, Huimin Zhang   +8 more
wiley   +1 more source

Analytical Validation of a Telomerase Reverse Transcriptase (TERT) Promoter Mutation Assay.

J Clin Endocrinol Metab
Iyer PC, Dadu R, Barque A, Zanelli C, Zheng X, Jiang H, Walsh PS, Hao Y, Huang J, Klopper JP, Kloos RT, Cabanillas M.   +11 more
europepmc   +1 more source