Results 41 to 50 of about 1,721,781 (403)

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring. [PDF]

, 2009
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring is not generally available in resource-limited settings. We examined switching from
Boulle, A, Braitstein, P, Brinkhof, Martin, Calmy, A, Dabis, F, Egger, Matthias, Jahn, A, Keiser, O, Keiser, Olivia, Kumarasamy, N, Lüthy, R, MacPhail, P, Nash, D, Pujades-Rodriguez, M, Schechter, M, Sprinz, E, Tuboi, S, Tweya, H, Wood, R   +18 more
core   +3 more sources

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

Journal of Biomedical Sciences, 2018
BackgroundLimitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation.
R. Leão, J. Apolónio, Donghyun D Lee, A. Figueiredo, U. Tabori, P. Castelo-Branco   +5 more
semanticscholar   +1 more source

Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation

mBio, 2023
Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or “retrotransposons,” mobilize through the production of an RNA intermediate that is then reverse transcribed to form complementary DNA
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Morgan M. O’Mara, Jez L. Marston, Tongyi Fei, Matthew L. Bendall, Douglas F. Nixon   +7 more
doaj   +1 more source

Antiretroviral treatment can affect the release of NO and EDCF, but EDH in rat arteries [PDF]

, 2012
This journal suppl. entitled: EDHF 2012 - 10th Anniversary MeetingDespite improving clinical outcomes, highly active antiretroviral therapy (HAART) is an independent potential risk factor for cardiovascular diseases.
Lee, SS, Leung, SWS, Nejad, A, Vanhoutte, PM   +3 more
core   +1 more source

Architecture of an HIV-1 reverse transcriptase initiation complex

Nature, 2018
Reverse transcription of the HIV-1 RNA genome into double-stranded DNA is a central step in viral infection1 and a common target of antiretroviral drugs2.
K. Larsen, Y. K. Mathiharan, K. Kappel, Aaron T. Coey, Dong-Hua Chen, Daniel J Barrero, Lauren Madigan, J. Puglisi, G. Skiniotis, E. V. Puglisi   +9 more
semanticscholar   +1 more source

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

Nature Communications, 2020
Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for ...
Mami Yasukawa, Yoshinari Ando, Taro Yamashita, Yoko Matsuda, Shisako Shoji, Masaki Suimye Morioka, Hideya Kawaji, Kumiko Shiozawa, Mitsuhiro Machitani, Takaya Abe, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Yasuhide Furuta, Tadashi Kondo, Mikako Shirouzu, Yoshihide Hayashizaki, Shuichi Kaneko, Kenkichi Masutomi   +18 more
doaj   +1 more source

Kinetic analysis of reverse transcriptase activity of bacterial family A DNA polymerases. [PDF]

, 2012
Some bacterial thermostable, wild-type or genetically engineered family A DNA polymerases have reverse transcriptase activity. However, difference in reverse transcriptase activities of family A DNA polymerases and retroviral reverse transcriptases (RTs)
Fujiwara, Shinsuke, Konishi, Atsushi, Nagaoka, Eriko, Shinomura, Mayu, Yasukawa, Kiyoshi   +4 more
core   +1 more source

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

New England Journal of Medicine, 2018
ART for the Aicardi–Goutieres Syndrome The genetic encephalopathy Aicardi–Goutieres syndrome is thought to be due to misidentification of self-derived nucleic acids and the induction of a type I in...
Gillian I. Rice, C. Meyzer, N. Bouazza, M. Hully, N. Boddaert, Michaela Semeraro, Leo A H Zeef, Flore Rozenberg, V. Bondet, D. Duffy, A. Llibre, Jinmi Baek, Mame N Sambe, Elodie Henry, V. Jolaine, C. Barnerias, Magalie Barth, Alexandre Bélot, C. Cances, F. Debray, D. Doummar, M. Frémond, Naoki Kitabayashi, A. Lepelley, Virginie Levrat, I. Melki, Pierre Meyer, Marie-Christine Nouguès, F. Renaldo, M. Rodero, Diana Rodriguez, A. Roubertie, L. Seabra, C. Uggenti, H. Abdoul, J. Treluyer, I. Desguerre, Stéphane Blanche, Y. Crow   +38 more
semanticscholar   +1 more source

Reverse Transcriptase and Retroviral Replication [PDF]

, 2011
142
Mar Álvarez, Verónica Barrioluengo, Luis Menéndez-Arias, Gilberto Betancor, Tania Matamoros   +4 more
openaire   +4 more sources

Inhibition of reverse transcriptases by seminalplasmin [PDF]

Biochemical Journal, 1983
Seminalplasmin, an antibacterial protein present in bovine seminal plasma, is shown to be a potent inhibitor of reverse transcriptases (RNA-dependent DNA nucleotidyltransferases). Seminalplasmin inhibits RNA-directed, hybrid-directed, and DNA-directed DNA-polymerizing activities of purified reverse transcriptase from avian myeloblastosis virus and from
M R Das, P M Bhargava, E S P Reddy, E P Reddy   +3 more
openaire   +3 more sources