Results 41 to 50 of about 1,758,180 (373)

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

Journal of Biomedical Sciences, 2018
BackgroundLimitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation.
R. Leão, J. Apolónio, Donghyun D Lee, A. Figueiredo, U. Tabori, P. Castelo-Branco   +5 more
semanticscholar   +1 more source

Architecture of an HIV-1 reverse transcriptase initiation complex

Nature, 2018
Reverse transcription of the HIV-1 RNA genome into double-stranded DNA is a central step in viral infection1 and a common target of antiretroviral drugs2.
K. Larsen, Y. K. Mathiharan, K. Kappel, Aaron T. Coey, Dong-Hua Chen, Daniel J Barrero, Lauren Madigan, J. Puglisi, G. Skiniotis, E. V. Puglisi   +9 more
semanticscholar   +1 more source

Lipometabolic side-effects of three ritonavir-boosted double protease inhibitor regimens without reverse transcriptase inhibitors [PDF]

, 2008
Poster presentation: Purpose of the study To compare the lipometabolic profiles of three double-boosted protease inhibitor (PI) regimens at standard dose, containing saquinavir and ritonavir in combination with lopinavir (LOPSAQ), atazanavir (ATSAQ) or ...
Bickel, Markus, Hentig, Nils von, Khaykin, Pavel, Knecht, Gaby, Lennemann, Tessa, Lutz, Thomas, Staszewski, Schlomo, Stephan, Christoph, Wendig, Annette   +8 more
core   +1 more source

Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation

mBio, 2023
Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or “retrotransposons,” mobilize through the production of an RNA intermediate that is then reverse transcribed to form complementary DNA
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Morgan M. O’Mara, Jez L. Marston, Tongyi Fei, Matthew L. Bendall, Douglas F. Nixon   +7 more
doaj   +1 more source

The regulations of telomerase reverse transcriptase (TERT) in cancer

Cell Death and Disease
Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in
Mingdi Liu, Yuning Zhang, Yongping Jian, Liting Gu, Dan Zhang, Honglan Zhou, Yishu Wang, Zhi-Xiang Xu   +7 more
semanticscholar   +1 more source

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

New England Journal of Medicine, 2018
ART for the Aicardi–Goutieres Syndrome The genetic encephalopathy Aicardi–Goutieres syndrome is thought to be due to misidentification of self-derived nucleic acids and the induction of a type I in...
Gillian I. Rice, C. Meyzer, N. Bouazza, M. Hully, N. Boddaert, Michaela Semeraro, Leo A H Zeef, Flore Rozenberg, V. Bondet, D. Duffy, A. Llibre, Jinmi Baek, Mame N Sambe, Elodie Henry, V. Jolaine, C. Barnerias, Magalie Barth, Alexandre Bélot, C. Cances, F. Debray, D. Doummar, M. Frémond, Naoki Kitabayashi, A. Lepelley, Virginie Levrat, I. Melki, Pierre Meyer, Marie-Christine Nouguès, F. Renaldo, M. Rodero, Diana Rodriguez, A. Roubertie, L. Seabra, C. Uggenti, H. Abdoul, J. Treluyer, I. Desguerre, Stéphane Blanche, Y. Crow   +38 more
semanticscholar   +1 more source

Allosteric HIV-1 integrase inhibitors lead to premature degradation of the viral RNA genome and integrase in target cells [PDF]

, 2017
Recent evidence indicates that inhibition of HIV-1 integrase (IN) binding to the viral RNA genome by allosteric integrase inhibitors (ALLINIs) or through mutations within IN yields aberrant particles in which the viral ribonucleoprotein complexes (vRNPs)
Elliott, Jennifer, Errando, Manel, Koneru, Pratibha C, Kutluay, Sebla B, Kvaratskhelia, Mamuka, Lawson, Dana Q, Madison, Michaela K, Ozanturk, Ayse Naz, Townsend, Dana   +8 more
core   +2 more sources

The Molecular Docking of Specific Reverse Transcriptase Inhibitory Ligands onto the Molecular Model of HIV-1 Reverse Transcriptase [PDF]

Trends in Pharmaceutical Sciences
HIV-1 reverse transcriptase (RT) is a crucial enzyme in HIV replication and AIDS progression. It consists of p66 and p51 subunits and converts viral RNA into double-stranded DNA for integration into the host cell's genome.
Roohallah Yousefi
doaj   +1 more source

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

Nature Communications, 2020
Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for ...
Mami Yasukawa, Yoshinari Ando, Taro Yamashita, Yoko Matsuda, Shisako Shoji, Masaki Suimye Morioka, Hideya Kawaji, Kumiko Shiozawa, Mitsuhiro Machitani, Takaya Abe, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Yasuhide Furuta, Tadashi Kondo, Mikako Shirouzu, Yoshihide Hayashizaki, Shuichi Kaneko, Kenkichi Masutomi   +18 more
doaj   +1 more source

Anti-HIV-1 activity of benzothiadiazine dioxide [PDF]

, 2013
Antiviral assays carried out on the potent benzothiadiazine dioxide (BTD) human cytomegalovirus (HCMV) inhibitors have led us to find marginal but selective anti-HIV-1 activity.
Balzarini, Jan, Castro, Ana, De Clercq, Erik, Gil, Carmen, Martínez, Ana, Pannecouque, C., Pérez, Concepción, Witvrouw, M.   +7 more
core   +2 more sources