Results 81 to 90 of about 568,137 (302)

Sprayable Polymer Blends With Short‐Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
Adhesions’ high occurrence rates and high morbidity render them a critical challenge to be addressed. Current prevention methods, such as physical barriers, have many limitations, resulting in inconsistent safety and efficacy. This study demonstrates the potential for sprayable polymeric materials as an adhesion barrier.
Robert J. Morris III, Tejaswi Nori, Alex I. Halpern, Hannah LaPadula, Arthur V. Cresce, Sarah L. Wright, Anthony D. Sandler, Peter Kofinas   +7 more
wiley   +1 more source

Methoxyflavones from as HIV-1 Reverse Transcriptase Inhibitors

Natural Product Communications, 2017
Methoxyflavones are flavonoid widely distributed in plants and has been reported as potent antitumor agents and some of them have shown activity against HIV-1. In this work, two methoxyflavones isolated from Marcetia taxifolia were evaluated in vitro and
Joseph T Ortega, María Luisa Serrano, Alírica I Suárez, Jani Baptista, Flor H Pujol, Héctor R Rangel   +5 more
doaj   +1 more source

Asymmetric conformational maturation of HIV-1 reverse transcriptase

eLife, 2015
HIV-1 reverse transcriptase utilizes a metamorphic polymerase domain that is able to adopt two alternate structures that fulfill catalytic and structural roles, thereby minimizing its coding requirements. This ambiguity introduces folding challenges that
Xunhai Zheng, Lalith Perera, Geoffrey A Mueller, Eugene F DeRose, Robert E London   +4 more
doaj   +1 more source

Characterization of endonuclease activities in Moloney murine leukemia virus and its replication-defective mutants [PDF]

, 1987
To study Moloney murine leukemia virus (M-MulV) proteins associated with the integration of proviral DNA into the host chromosome, we isolated endonuclease activities from purified virion preparations of the wild type and two of its replication mutants ...
Baltimore, David, Panet, Amos
core  

Effectiveness of highly active antiretroviral therapy in HIV-positive children: evaluation at 12 months in a routine program in Cambodia. [PDF]

, 2007
OBJECTIVE: Increasing access to highly active antiretroviral therapy to reach all those in need in developing countries (scale up) is slowly expanding to HIV-positive children, but documented experience remains limited. We aimed to describe the clinical,
Akao, K, Ford, N, Gupta, J, Janssens, B, Nerrienet, E, Nouhin, J, Raleigh, B, Soeung, S, Te, V, Vun, M   +9 more
core   +2 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance

Scientifica, 2012
The use of highly active antiretroviral therapy (HAART) involves combinations of drugs to achieve maximal virological response and reduce the potential for the emergence of antiviral resistance.
Mark A. Wainberg
doaj   +1 more source

Lipometabolic side-effects of three ritonavir-boosted double protease inhibitor regimens without reverse transcriptase inhibitors [PDF]

, 2008
Poster presentation: Purpose of the study To compare the lipometabolic profiles of three double-boosted protease inhibitor (PI) regimens at standard dose, containing saquinavir and ritonavir in combination with lopinavir (LOPSAQ), atazanavir (ATSAQ) or ...
Bickel, Markus, Hentig, Nils von, Khaykin, Pavel, Knecht, Gaby, Lennemann, Tessa, Lutz, Thomas, Staszewski, Schlomo, Stephan, Christoph, Wendig, Annette   +8 more
core   +1 more source

Phosphonoformate Inhibits Reverse Transcriptase

Journal of General Virology, 1979
The new antiviral substance phosphonoformate (PFA) has been tested in a cell-free system for its effect on reverse transcriptases from an avian retrovirus (avian myeloblastosis virus, AMV) and from mammalian retroviruses (Rauscher leukaemia virus, RMuLV; bovine leukaemia virus; baboon endogenous virus; simian sarcoma virus; visna virus).
B, Sundquist, B, Oberg
openaire   +2 more sources

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source