Results 241 to 250 of about 1,271,708 (300)

HIV nucleoside reverse transcriptase inhibitors

European Journal of Medicinal Chemistry, 2022
More than 40 years into the pandemic, HIV remains a global burden and as of now, there is no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been developed to manage and suppress HIV infection. Combinations of two to three drugs targeting key viral proteins, including compounds inhibiting HIV reverse transcriptase (RT ...
Raymond Schinazi, Maryam Ehteshami, Eleftherios Michailidis   +2 more
exaly   +3 more sources

The Nucleoside Reverse Transcriptase Inhibitors, Nonnucleoside Reverse Transcriptase Inhibitors, and Protease Inhibitors in the Treatment of HIV Infections (AIDS)

, 2013
The majority of the drugs currently used for the treatment of HIV infections (AIDS) belong to either of the following three classes: nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs).
Erik De Clercq, De Clercq, Erik
openaire   +3 more sources

HIV resistance to reverse transcriptase inhibitors

Biochemical Pharmacology, 1994
Erik de Clercq
exaly   +3 more sources

Investigational reverse transcriptase inhibitors for the treatment of HIV

Expert Opinion on Investigational Drugs, 2015
INTRODUCTION: While considerable advances have been made in the development of antiretroviral agents, there is still work to be done. Reverse transcriptase inhibitors are important drugs for the treatment of HIV, and considerable research is currently ...
Santosh Kumar, Theodore Cory, Narasimha M Midde   +2 more
exaly   +2 more sources

Reverse Transcriptase Inhibitors as Microbicides

Current HIV Research, 2012
The CAPRISA 004 study in South Africa has accelerated the development of vaginal and rectal microbicides containing antiretrovirals that target specific enzymes in the reproduction cycle of HIV, especially reverse transcriptase inhibitors (RTI). In this review we discuss the potential relevance of HIV-1 RTIs as microbicides, focusing in the nucleotide ...
Lewi, P., Heeres, J., Ariën, K., Venkatraj, M., Joossens, J., Van der Veken, P., Augustyns, K., Vanham, G.   +7 more
openaire   +3 more sources

HIV-1 reverse transcriptase inhibitors

Applied Microbiology and Biotechnology, 2007
Reverse transcriptase (RT) is one of the three enzymes encoded by the human immunodeficiency virus type 1 (HIV-1), the etiological agent of AIDS. Together with protease inhibitors, drugs inhibiting the RNA- and DNA-dependant DNA polymerase activity of RT are the major components of highly active antiretroviral therapy (HAART), which has dramatically ...
El Safadi, Yazan, Vivet-Boudou, Valérie, Marquet, Roland   +2 more
openaire   +3 more sources

Hepatotoxicity of Nucleoside Reverse Transcriptase Inhibitors

Seminars in Liver Disease, 2003
Hepatotoxicity is an adverse effect of all available classes of antiretrovirals, including nucleoside reverse transcriptase inhibitors (NRTI). A syndrome of hepatic steatosis and lactic acidosis has been recognized as a rare, potentially fatal complication since the advent of NRTI monotherapy in the early 1990s.
Valentina, Montessori, Marianne, Harris, Julio S G, Montaner   +2 more
openaire   +2 more sources

Mechanism of the action of the inhibitor of reverse transcriptase

Biochemical and Biophysical Research Communications, 1984
An inhibitor of reverse transcriptase of Moloney leukemia virus was reported previously in the cytoplasm of the cultured cells (1). In this report, the mechanism of the inhibition was examined. The inhibitory activity was completely abrogated by treatment at 55 degrees C for 20 min.
M, Rokutanda, S T, Watanabe, Y Y, Maeda
openaire   +2 more sources

New Reverse Transcriptase Inhibitors

1999
Reverse transcriptase inhibitors used in the treatment of HIV-1 infection include the nucleoside analogues zidovudine, didanosine, zalcitabine, lamivudine and stavudine. More recently a number of other classes of reverse transcriptase inhibitors have been discovered, and are in various phases of clinical trial. This chapter will focus on the nucleoside
openaire   +2 more sources

HIV Inhibitors Targeted at the Reverse Transcriptase

AIDS Research and Human Retroviruses, 1992
HIV inhibitors targeted at the virus-associated reverse transcriptase (RT) can be divided into two groups, depending on whether they are targeted at the substrate or nonsubstrate binding site. To the first group belong the 2′,3′-dideoxynucleosides (i.e., DDC, DDI), 3′-azido-2′,3′-dideoxynucleosides (i.e., AZT), 3′-fluoro-2′,3 ...
openaire   +2 more sources