Reverse transcriptase inhibitors

Results 291 to 300 of about 399,014 (392)

Rapid and Sensitive Detection of RNA Viruses through Imaging of Marker Molecules Derived from Designed Circular DNA Probes

Small Methods, EarlyView.
This study presents a rapid and sensitive virus detection method that employs imaging of virus‐specific DNA markers. Utilizing specially designed single‐stranded circular DNA probes, this method captures RNA fragments from RNase‐digested viral genomes during the reverse transcriptase‐based reaction, resulting in double‐stranded markers that are ...
Yoon‐ha Jang +13 more
wiley +1 more source

Effects of Bone Morphogenetic Protein‐7 on Steroid‐Induced Extracellular Matrix Accumulation in Human Trabecular Meshwork Cells

FASEB BioAdvances, EarlyView.
Long‐term steroid use can elevate intraocular pressure (IOP) and lead to steroid‐induced glaucoma by promoting extracellular matrix (ECM) accumulation in the trabecular meshwork (TM). This study demonstrates that bone morphogenetic protein‐7 (BMP‐7), delivered via a micellized protein transduction domain (mPTD), effectively inhibits steroid‐induced ECM
Eun Woo Kim +9 more
wiley +1 more source

Incomplete Genotypic Resistance to Nonnucleoside Reverse Transcriptase Inhibitors in Patients Treated With Nevirapine: A Potential Interest in Clinical Practice

, 2000
Michèle Grappin +6 more
openalex +1 more source

The transformer gene controls sexual development in Drosophila suzukii

Insect Science, EarlyView.
The transformer gene plays a key role in the genetic pathway for sexual development in Drosophila suzukii Abstract The genetic network of sex determination in the model organism Drosophila melanogaster was investigated in great detail. Such knowledge not only advances our understanding of the evolution and regulation of sexual dimorphism in insects ...
Ying Yan +8 more
wiley +1 more source

Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors

Antimicrobial Agents and Chemotherapy, 2012
Eugene Asahchop +3 more
semanticscholar +1 more source

Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries. [PDF]

Viruses
Gouissi Anguechia DH +19 more
europepmc +1 more source

Development of a Short Telomere Zebrafish Model for Accelerated Aging Research and Antiaging Drug Screening

Aging Cell, EarlyView.
Larvae derived from a cross between tert deficient and haploinsufficient fish show a premature aging phenotype, characterized by telomere attrition and early death. The ST2 larval model is a valuable tool for rapid screening of antiaging molecules. Given that organogenesis occurs within the first 48 h, this model also allows for the conduction of aging
David Hernández‐Silva +5 more
wiley +1 more source

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria

Aging Cell, EarlyView.
TERT circRNA outperforms linear TERT mRNA in reversing the hallmarks of senescence. TERT circRNA more efficiently restores endothelial function and shows superior capability in enhancing mitochondrial function. ABSTRACT Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells,
Weifeng Qin +6 more
wiley +1 more source

Nonnucleoside reverse transcriptase inhibitors as anti-HIV-1 microbicides

, 2001
Michael A. Parniak
openalex +1 more source

humans
3. good health
hiv infections

anti-hiv agents
hiv-1
hiv reverse transcriptase

drug resistance, viral
nucleosides
rna-directed dna polymerase