Results 91 to 100 of about 269,716 (296)

Culex tarsalis is a competent vector species for Cache Valley virus [PDF]

, 2018
Background: Cache Valley virus (CVV) is a mosquito-borne orthobunyavirus endemic in North America. The virus is an important agricultural pathogen leading to abortion and embryonic lethality in ruminant species, especially sheep.
Alto, Barry W., Ayers, Victoria B., Blitvich, Bradley J., Dunlop, James I., Higgs, Stephen, Huang, Yan-Jang, Kohl, Alain, Lyons, Amy C., Park, So Lee, Unlu, Isik, Vanlandingham, Dana L.   +10 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]

, 1994
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Bahn, Rebecca S., Dutton, Charyl M., Heufelder, Armin E., Sarkar, Gobinda   +3 more
core   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Possible Central Nervous System Infection by SARS Coronavirus

Emerging Infectious Diseases, 2004
On day 22 of illness, generalized tonic-clonic convulsion developed in a 32-year-old woman with severe acute respiratory syndrome (SARS). Cerebrospinal fluid tested positive for SARS coronavirus (SARS-CoV) by reverse transcriptase–polymerase chain ...
Kwok-Kwong Lau, Wai-Cho Yu, Chung-Ming Chu, Suet-Ting Lau, Bun Sheng, K.Y. Yuen   +5 more
doaj   +1 more source

HLA-G: expression in human keratinocytes in vitro and in human skin in vivo [PDF]

, 1994
Classical, polymorphic major histocompatibility complex class I molecules are expressed on most nucleated cells.They present peptides at the cell surface and, thus, enable the immune system to scan peptides for their antigenicity.
Ulbrecht, M., Rehberger, B., Strobel, I., Messer, Gerald, Kind, P., Degitz, K., Bieber, T., Weiss, Elisabeth H.   +7 more
core   +2 more sources

SDS‐CRISPR for Single‐Nucleotide Variant Detection

Advanced Science, EarlyView.
Structure‐disruption‐sensitive CRISPR (SDS‐CRISPR) converts structural instability into single‐nucleotide precision, thereby overcoming mismatch tolerance in canonical Cas12a and enabling versatile diagnostics across DNA, RNA, and microRNA targets. When applied to rapid IDH1 mutation detection for glioma genotyping and integrated with lateral‐flow ...
Xin Guan, Chong Guo, Jiongyu Zhang, Rui Yang, Yerramsetti Ramachandra, Chengyu Hou, Minjie Pei, Shuo Zhang, Kurt T. Schalper, Xingye Liu, Qian Wu, Ketan R. Bulsara, Changchun Liu   +12 more
wiley   +1 more source

Norwalk-Like Viral Gastroenteritis Outbreak in U.S. Army Trainees

Emerging Infectious Diseases, 2000
An outbreak of acute gastroenteritis hospitalized 99 (12%) of 835 U.S. Army trainees at Fort Bliss, El Paso, Texas, rom August 27 to September 1, 1998.
Mark K. Arness, Brian H. Feighner, Michelle L. Canham, David N. Taylor, Stephan S. Monroe, Theodore J. Cieslak, Edward L. Hoedebecke, Christina S. Polyak, Judy C. Cuthie, Rebecca L. Fankhauser, Charles D. Humphrey, Tamra L. Barker, Chris D. Jenkins, Donald R. Skillman   +13 more
doaj   +1 more source

An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family [PDF]

, 2014
A mutant of the high fidelity family-B DNA polymerase from the archaeon Thermococcus gorgonarius (Tgo-Pol), able to replicate past DNA lesions, is described.
Aidan J. Doherty, Barry, Bebenek, Bernard A. Connolly, Biles, Boiteux, Braithwaite, Brautigam, Brian J. Keith, Burgers, Cadet, Cann, Cann, Cline, Cozens, Cubonová, Fenton, Firbank, Franklin, Gan, Goodman, Haracska, Haracska, Heller, Hogg, Ishino, Johnson, Johnson, Johnson, Joyce, Jozwiakowski, Jozwiakowski, Keith, Kelley, Kelman, Kim, Kunkel, Kunkel, Lawrence, Lawrence, Lawrence, Leadon, Leigh, Louise Gilroy, Lundberg, McCulloch, Nick McElhinny, Northam, Perera, Pettersen, Pfeifer, Prakash, Pursell, Rangarajan, Reha-Krantz, Sabouri, Sabouri, Sarmiento, Schneider, Shaw, Stanislaw K. Jozwiakowski, Stillman, Swan, Teoule, Terpe, Wang, Wang, Waters, Yang   +68 more
core   +1 more source

Interface Wettability Transition‐Driven Drug Release and Dual‐Phase Functionalization in Implant Abutment

Advanced Science, EarlyView.
A temporally controlled drug release coating is developed for abutments using a superhydrophobic coating self‐assembled on mesoporous silica. This surface provides sequential functionality: initial contamination resistance through non‐wetting, followed by controlled drug release via wettability transition.
Zhongchao Wang, Liang Shi, MingXia Li, Xiao Han, Jinghan Wang, Guangping Wang, Dan Zou, Bingyang Lu, Liyuan Fan   +8 more
wiley   +1 more source