Targeting the SOD1‒MMP‐2‒COLXVII axis: A therapeutic strategy for age‐related tissue degeneration
VIEW, EarlyView.Our work identifies a novel role for MMP‐2 in driving senescence‐associated skin and muscle degeneration through ECM degradation. We demonstrate that inhibiting MMP‐2 activity restores tissue integrity by preserving COLXVII, revealing a new therapeutic pathway for combating oxidative stress‐induced tissue aging. Using both mammalian and nematode models,
Juewon Kim +8 more
wiley +1 more source
Direct detection of canine picornavirus complete coding sequence in wastewater using long-range reverse-transcriptase polymerase chain reaction and long-read sequencing. [PDF]
Infect Genet EvolFaleye TOC +5 more
europepmc +1 more source
The transformer gene controls sexual development in Drosophila suzukii
Insect Science, EarlyView.The transformer gene plays a key role in the genetic pathway for sexual development in Drosophila suzukii Abstract The genetic network of sex determination in the model organism Drosophila melanogaster was investigated in great detail. Such knowledge not only advances our understanding of the evolution and regulation of sexual dimorphism in insects ...
Ying Yan +8 more
wiley +1 more source
Glass eels and viruses – a lesson learnt from stocking the eastern German Baltic Sea coast
Transboundary and Emerging Diseases, Accepted Article., 2022 Abstract Concerns about Anguillid herpesvirus 1 (AngHV‐1) in European eels, especially due to stocking measures, is increasingly coming into focus and raises questions regarding disease monitoring and prevention. In the past, stocking of AngHV‐1‐positive eels into waters assumed AngHV‐1‐free has led to a rapid increase of infected eels in the wild. For
Laura Kullmann +3 more
wiley +1 more source
A Patient with COVID-19 Presenting a False-Negative Reverse Transcriptase Polymerase Chain Reaction Result. [PDF]
Korean J Radiol, 2020 Chen Z +5 more
europepmc +1 more source
Detection and differentiation of pathogenicity of avian paramyxovirus serotype 1 from field cases using one-step reverse transcriptase-polymerase chain reaction [PDF]
, 2002 Julie L. Creelan +2 more
openalex +1 more source
Virus‐Induced Cellular Senescence Causes Pulmonary Sequelae Post‐Influenza Infection
Aging Cell, EarlyView.Genetic or pharmacological depletion of senescent cells during influenza A virus infection led to complete recovery of the airway epithelium, indicating a marked acceleration of the epithelial repair process. Targeting senescent cells may represent a new preventive therapeutic option to reduce post‐influenza chronic lung damage.
Larissa Lipskaia +20 more
wiley +1 more source
Outcomes of symptom screening and universal COVID-19 reverse transcriptase polymerase chain reaction testing before endoscopy in a community-based ambulatory surgery center. [PDF]
Gastrointest Endosc, 2021 Bowyer B +7 more
europepmc +1 more source
Preoperative evidence of circulating tumor cells by means of reverse transcriptase-polymerase chain reaction for carcinoembryonic antigen messenger RNA is an independent predictor of survival in non–small cell lung cancer: A prospective study [PDF]
, 2002 Jun‐ichi Yamashita +5 more
openalex +1 more source