Results 181 to 190 of about 657,904 (378)

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

Advanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, Pier Paolo Di Fiore, Daniela Tosoni   +16 more
wiley   +1 more source

Simultaneous and rapid detection of avian respiratory diseases of small poultry using multiplex reverse transcription-Polymerase Chain Reaction assay. [PDF]

Poult Sci, 2023
Piri-Gharaghie T, Ghajari G, Lahijani NT, Pecho RDC, Hussam F, Castillo-Acobo RY, Aghassizadeh-Sherbaf M.   +6 more
europepmc   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

Real-time quantitative reverse transcription polymerase chain reaction detection of SARS-CoV-2 Delta variant in Canadian wastewater. [PDF]

Can Commun Dis Rep, 2023
Peterson S, Daigle J, Dueck C, Nagasawa A, Mulvey M, Mangat CS.   +5 more
europepmc   +1 more source

Detection of HOP Latent Viroid(HLVd) Using Reverse Transcription and Polymerase Chain Reaction(RT-PCR).

, 1992
Tatsuji Hataya, Katsuyuki Hikage, Narushi Suda, Tatsuya Nagata, Shifang Li, Yutaka Itoga, Tokio TANIKOSHI, Eishiro Shikata   +7 more
openalex   +2 more sources

Cohen NS (1996): Intracellular localization of the mRNAs of argininosuccinate synthetase and argininosuccinate lyase around liver mitochondria, visualized by high‐resolution in situ reverse transcription‐polymerase chain reaction. J Cell Biochem 61:81‐96. [PDF]

, 1996
Cohen
openalex   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

Multiplex Reverse Transcription Polymerase Chain Reaction Combined with a Microwell Hybridization Assay Screening for Arbovirus and Parasitic Infections in Febrile Patients Living in Endemic Regions of Colombia. [PDF]

Trop Med Infect Dis, 2023
Calderon-Ruiz P, Haist G, Mascus A, Holguin-Rocha AF, Koliopoulos P, Daniel T, Velez G, Londono-Renteria B, Gröndahl B, Tobon-Castano A, Gehring S.   +10 more
europepmc   +1 more source

Detection of Tomato Spotted Wilt Virus S RNA in Individual Thrips by Reverse Transcription and Polymerase Chain Reaction.

, 1994
Shinya Tsuda, I Fujisawa, Kaoru Hanada, Soh Hidaka, Kenichi Higo, Mitsuro KAMEYA-IWAKI, Keiichi Tomaru   +6 more
openalex   +2 more sources

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source