Results 231 to 240 of about 329,236 (311)

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, EarlyView.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Establishment and Application of a Quadruplex Real-Time Reverse-Transcription Polymerase Chain Reaction Assay for Differentiation of Porcine Reproductive and Respiratory Syndrome Virus, Porcine Circovirus Type 2, Porcine Circovirus Type 3, and Streptococcus suis. [PDF]

Microorganisms
Wang G, Zhu H, Zhan C, Chen P, Wu B, Peng Z, Qian P, Cheng G.   +7 more
europepmc   +1 more source

NIR Driven Pd/Cerium Oxide Nano‐Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy

Advanced Science, EarlyView.
In vivo SALI therapy is achieved by scavenging intracellular ROS levels, downregulating inflammatory factors expression levels, inducing macrophage M2 directional polarization, and activating Keap1/Nrf‐2/HO‐1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation, and promote liver tissue repair. Abstract Sepsis
Tao Qin, Lian Qin, Yang Zhao, Yin Chen, Qianyue Liu, Xiaoguang Lin, Yongfeng Lan, Yaohui Huang, Yan Liu, Ke Zhang, Lifan Pan, Jiaxiao Li, Kunpeng Duan, Hao Liang, Mingjing Yin, Guiyang Fan, Lian Liu, Yu Deng, Lin Liao, Danke Su, Ming Gao, Junyu Lu   +21 more
wiley   +1 more source

Fukuchi-Manabe Score for Infection Control Measures During the Very Early COVID-19 Pandemic Period When Access to Reverse Transcription-Polymerase Chain Reaction Testing Was Poor in Japan: A Single-Center Observational Prospective Cohort Study. [PDF]

Cureus
Fukuchi T, Oyama-Manabe N, Sugawara H.
europepmc   +1 more source

Cytokine expression of lung and small intestinal in experimental abdominal aortic ischemia-reperfusion injury in rabbits: a semiquntitation of reverse transcription-polymerase chain reaction analysis Harry H. Liu, Nicholas J. Morrissey, Ikka Kantonen, Shepard Weiner, Sumit De, Morris D.Kerstein, Larry H. Hollier. Mount Sinai Medical Center, New York, NY

, 2001

openalex   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

Advanced Science, EarlyView.
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye, Shi Li, Guofang Bi, Binghui Li, Zhai Cai, Meixian Jin, Ying Zhang, Wanren Yang, Yang Li, Shao Li, Wei Hu, Yi Gao, Mingxin Pan, Shuqin Zhou, Chao Zhang, Huichang Bi, Qing Peng   +16 more
wiley   +1 more source

Evaluation of the Reverse Transcription-Polymerase Chain Reaction/Probe Test of Serum Samples and Immunohistochemistry of Skin Sections for Detection of Acute Bovine Viral Diarrhea Infections

, 2002
Julia F. Ridpath, Sharon K. Hietala, Steve Sorden, John D. Neill   +3 more
openalex   +1 more source

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis

Advanced Science, EarlyView.
The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang   +5 more
wiley   +1 more source