Results 81 to 90 of about 760,511 (339)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Reversible Logic Synthesis

Безопасность информационных технологий, 2013
Reversibility of ongoing transformation may soon become an important criterion for logic synthesis. It was proved that every even permutation can be implemented without temporary storage using NOT, CNOT, and TOFFOLI gates. There exists group theory based
Dmitry Vladimirovich Zakablukov
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Different quantum f-divergences and the reversibility of quantum operations [PDF]

, 2016
The concept of classical $f$-divergences gives a unified framework to construct and study measures of dissimilarity of probability distributions; special cases include the relative entropy and the Renyi divergences.
F. Hiai, M. Mosonyi
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Highly Selective Dual Channel Chemosensor Based on benzo[d]thiazole for Detection of Zn2+ ions

International Journal of Electrochemical Science, 2016
A cost effective reversible dual channel chemosensor (BT-1) has been synthesized for detection of Zn2+ ion based on a benzo[d]thiazole Schiff base. It exhibits high selective and sensitive optical changes in fluorescence intensity for zinc metal ions ...
Lokesh Kumar Kumawat, Vinod Kumar Gupta
doaj   +1 more source

Onsager reciprocity relations without microscopic reversibility

, 1995
In this paper we show that Onsager--Machlup time reversal properties of thermodynamic fluctuations and Onsager reciprocity relations for transport coefficients can hold also if the microscopic dynamics is not reversible.
C. Kipnis, C. Landim, D. Gabrielli, D. Gabrielli, G. Eyink, G. Eyink, G. Jona-Lasinio, G. Jona-Lasinio, L. Onsager, L. Onsager, M. Donsker   +10 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Second law, entropy production, and reversibility in thermodynamics of information

, 2017
We present a pedagogical review of the fundamental concepts in thermodynamics of information, by focusing on the second law of thermodynamics and the entropy production.
A Bérut, A Bérut, AB Boyd, AB Boyd, AB Boyd, AC Barato, AC Barato, AC Barato, AC Barato, AH Lang, B Gaveau, B Piechocinska, C Broeck Van den, C Jarzynski, C Jarzynski, C Jarzynski, C Kwon, C Moore, C Shannon, CH Bennett, CY Mou, D Abreu, D Abreu, D Hartich, D Kondepudi, D Mandal, D Reeb, DJ Evans, DJ Evans, E Iyoda, E Roldan, EH Lieb, F Curzon, FGSL Brandão, FJ Cao, G Gallavotti, G Lan, GE Crooks, GN Bochkov, H Matsueda, H Tajima, H Touchette, H Touchette, HB Callen, J Goold, J Hong, J Schnakenberg, JC Maxwell, JJ Park, JM Horowitz, JM Horowitz, JM Horowitz, JM Horowitz, JM Horowitz, JM Horowitz, JMR Parrondo, JPP Silva, JV Koski, JV Koski, K Chida, K Funo, K Jacobs, K Kawasaki, K Saito, K Sekimoto, K Shizume, KH Kim, L Brillouin, L Rio del, L Szilard, M Esposito, M Esposito, M Esposito, M Gavrilov, M Gavrilov, M Gavrilov, M Horodecki, M Lopez-Suarez, M Rigol, MA Nielsen, MD Vidrighin, ML Rosinberg, N Cottet, N Shiraishi, N Shiraishi, N Shiraishi, P Mehta, P Sartori, P Sartori, P Strasberg, P Strasberg, PA Camati, R Dillenschneider, R Kawai, R Landauer, R Landauer, S Ciliberto, S Deffner, S Ito, S Ito, S Lahiri, S Lloyd, S Popescu, S Still, S Toyabe, S Turgut, S Yamamoto, SW Kim, T Campisi, T J Kobayashi, T Munakata, T Sagawa, T Sagawa, T Sagawa, T Sagawa, T Sagawa, T Sagawa, T Sagawa, T Schreiber, TE Ouldridge, TE Ouldridge, TM Cover, U Seifert, U Seifert, WC Gardiner, WH Zurek, Y Fujitani, Y Jun, Y Morikuni, À M Alhambra   +129 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source