Results 91 to 100 of about 96,351 (269)

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Hysteresis and irreversibility of global drought patterns in response to CO2 mitigation efforts

Environmental Research Letters
Drought is expected to intensify with rising CO _2 , but its behavior under CO _2 mitigation, remains uncertain. The response of the climate system to CO _2 variation exhibits hysteresis and irreversibility, highlighting the difficulty of recovery and ...
Sanjit Kumar Mondal, Soon-Il An, Seung-Ki Min, Tong Jiang, Buda Su, Seungmok Paik, Soong-Ki Kim   +6 more
doaj   +1 more source

Reverse Training to Nurse the Reversal Curse

CoRR
Large language models (LLMs) have a surprising failure: when trained on "A has a feature B", they do not generalize to "B is a feature of A", which is termed the Reversal Curse. Even when training with trillions of tokens this issue still appears due to Zipf's law - hence even if we train on the entire internet.
Olga Golovneva, Zeyuan Allen-Zhu, Jason Weston, Sainbayar Sukhbaatar   +3 more
openaire   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

A review on realizing rechargeable batteries based on SOCl2/SO2 electrolyte systems

MetalMat
As representative high‐energy density primary batteries, Li‐SOCl2 and Li‐SO2 batteries possess superiorities including high working potential, long temperature range, low self‐discharge rate and high safety compared with other conventional primary ...
Xiangyu Gao, Guodong Chen, Jinran Sun, Shanmu Dong, Guanglei Cui   +4 more
doaj   +1 more source

Direct Synthesis of LiAlH₄ from Ti-Doped Active LiAl Alloy

Inorganics
LiAlH4, characterized by high hydrogen capacity and metastable properties, is regarded as a promising hydrogen source under mild conditions. However, its reversible regeneration from dehydrogenated production is hindered thermodynamically and kinetically.
Yan Chu, Shiwei Fang, Yingjue Chen, Xiaoqi Zhang, Jie Zheng, Zhenglong Li, Wubin Du, Wengang Cui, Jian Miao, Yaxiong Yang, Yongfeng Liu, Mingxia Gao, Hongge Pan   +12 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

What is the Best Way to Diagnose Possible Asthma Patients with Negative Bronchodilator Reversibility Tests?

Journal of Asthma and Allergy
Buket Başa Akdoğan, Ilkay Koca Kalkan, Gözde Köycü Buhari, Özlem Özdedeoğlu, Hale Ateş, Kurtuluş Aksu, Ferda Öner Erkekol Department of Chest Diseases, Division of Immunology and Allergy, University of Health Sciences ...
Başa Akdoğan B, Koca Kalkan I, Köycü Buhari G, Özdedeoğlu Ö, Ateş H, Aksu K, Öner Erkekol F   +6 more
doaj